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Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta
المؤلفون المشاركون
Rice, Gregory E.
Mitchell, Murray D.
Nitert, Marloes Dekker
Vaswani, Kanchan
Chan, Hsiu-Wen
Peiris, Hassendrini N.
Wood Bradley, Ryan J.
Armitage, James A.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Mammalian placentation is a vital facet of the development of a healthy and viable offspring.
Throughout gestation the placenta changes to accommodate, provide for, and meet the demands of a growing fetus.
Gestational gene expression is a crucial part of placenta development.
The endocannabinoid pathway is activated in the placenta and decidual tissues throughout pregnancy and aberrant endocannabinoid signaling during the period of placental development has been associated with pregnancy disorders.
In this study, the gene expression of eight endocannabinoid system enzymes was investigated throughout gestation.
Rat placentae were obtained at E14.25, E15.25, E17.25, and E20, RNA was extracted, and microarray was performed.
Gene expression of enzymes Faah, Mgll, Plcd4, Pld1, Nat1, Daglα, and Ptgs2 was studied (cohort 1, microarray).
Biological replication of the results was performed by qPCR (cohort 2).
Four genes showed differential expression (Mgll, Plcd4, Ptgs2, and Pld1), from mid to late gestation.
Genes positively associated with gestational age were Ptgs2, Mgll, and Pld1, while Plcd4 was downregulated.
This is the first comprehensive study that has investigated endocannabinoid pathway gene expression during rat pregnancy.
This study provides the framework for future studies that investigate the role of endocannabinoid system during pregnancy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vaswani, Kanchan& Chan, Hsiu-Wen& Peiris, Hassendrini N.& Nitert, Marloes Dekker& Wood Bradley, Ryan J.& Armitage, James A.…[et al.]. 2015. Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072611
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vaswani, Kanchan…[et al.]. Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072611
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vaswani, Kanchan& Chan, Hsiu-Wen& Peiris, Hassendrini N.& Nitert, Marloes Dekker& Wood Bradley, Ryan J.& Armitage, James A.…[et al.]. Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072611
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072611
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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