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Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL6 Mice Fed a Low-Fat Diet
المؤلفون المشاركون
Wu, Shao-Chun
Rau, Cheng-Shyuan
Lu, Tsu-Hsiang
Wu, Yi-Chan
Tzeng, Siou-Ling
Wu, Chia-Jung
Hsieh, Ching-Hua
Lin, Chia-Wei
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-23
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
This study aims to investigate the effect of feeding low-fat diet (LFD) to diet-induced obesity (DIO) mice lacking TLR5 (TLR5−/−), which have a tendency to develop glucose intolerance with increased adiposity, compared to that in C57BL/6 mice.
Results.
TLR5−/− and C57BL/6 male mice were divided into three subgroups: (1) control, mice were fed a standard AIN-76A (fat: 11.5 kcal%) diet for 12 weeks; (2) DIO, mice were fed a 58 kcal% high-fat diet (HFD) for 12 weeks; and (3) diet, mice were fed a HFD for 8 weeks to induce obesity and then switched to a 10.5 kcal% LFD for 4 weeks.
The glucose intolerance in DIO TLR5−/− mice was more significant than that in DIO C57BL/6 mice and was not attenuated by a switch to the LFD.
Weight-reduction with LFD had significantly decreased the epididymal fat mass in C57BL/6 mice but not in TLR5−/− mice.
In addition, the LFD-fed TLR5−/− mice showed significantly higher expression of ghrelin in the serum and resistin in the epididymal fat than that in C57BL/6 mice.
Conclusions.
This study demonstrated that TLR5 gene knockout impairs some effects of weight-reduction in DIO.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Shao-Chun& Rau, Cheng-Shyuan& Lu, Tsu-Hsiang& Tzeng, Siou-Ling& Wu, Yi-Chan& Wu, Chia-Jung…[et al.]. 2015. Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL6 Mice Fed a Low-Fat Diet. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072612
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Shao-Chun…[et al.]. Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL6 Mice Fed a Low-Fat Diet. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072612
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Shao-Chun& Rau, Cheng-Shyuan& Lu, Tsu-Hsiang& Tzeng, Siou-Ling& Wu, Yi-Chan& Wu, Chia-Jung…[et al.]. Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL6 Mice Fed a Low-Fat Diet. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072612
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072612
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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