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Normal Metabolic Levels in Prefrontal Cortex in Euthymic Bipolar I Patients with and without Suicide Attempts
المؤلفون المشاركون
Rocha, Marlos Vasconcelos
Nery-Fernandes, Fabiana
Guimarães, José Luiz
Quarantini, Lucas de Castro
de Oliveira, Irismar Reis
Ladeia-Rocha, Giovanna G.
Jackowski, Andrea Parolin
de Araujo Neto, César
Miranda-Scippa, Ângela
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction/Objective.
Evidence suggests that the prefrontal cortex has been implicated in the pathophysiology of bipolar disorder (BD), but few neurochemical studies have evaluated this region in bipolar patients and there is no information from BD suicide attempters using Proton Magnetic Resonance Spectroscopy (H+MRS).
The objective was to evaluate the metabolic function of the medial orbital frontal cortex in euthymic BD type I suicide and nonsuicide attempters compared to healthy subjects by H+MRS.
Methods.
40 euthymic bipolar I outpatients, 19 without and 21 with history of suicide attempt, and 22 healthy subjects were interviewed using the Structured Clinical Interview with the DSM-IV axis I, the Hamilton Depression Rating Scale, the Young Mania Rating Scale, and the Barratt Impulsiveness Scale-11 and underwent H+MRS.
Results.
We did not find any metabolic abnormality in medial orbital frontal regions of suicide and nonsuicide BD patients and BD patients as a group compared to healthy subjects.
Conclusions.
The combined chronic use of psychotropic drugs with neuroprotective or neurotrophic effects leading to a euthymic state for longer periods of time may improve neurometabolic function, at least measured by H+MRS, even in suicide attempters.
Besides, these results may implicate mood dependent alterations in brain metabolic activity.
However, more studies with larger sample sizes of this heterogeneous disorder are warranted to clarify these data.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rocha, Marlos Vasconcelos& Nery-Fernandes, Fabiana& Guimarães, José Luiz& Quarantini, Lucas de Castro& de Oliveira, Irismar Reis& Ladeia-Rocha, Giovanna G.…[et al.]. 2015. Normal Metabolic Levels in Prefrontal Cortex in Euthymic Bipolar I Patients with and without Suicide Attempts. Neural Plasticity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075296
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rocha, Marlos Vasconcelos…[et al.]. Normal Metabolic Levels in Prefrontal Cortex in Euthymic Bipolar I Patients with and without Suicide Attempts. Neural Plasticity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075296
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rocha, Marlos Vasconcelos& Nery-Fernandes, Fabiana& Guimarães, José Luiz& Quarantini, Lucas de Castro& de Oliveira, Irismar Reis& Ladeia-Rocha, Giovanna G.…[et al.]. Normal Metabolic Levels in Prefrontal Cortex in Euthymic Bipolar I Patients with and without Suicide Attempts. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075296
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075296
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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