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Normal Metabolic Levels in Prefrontal Cortex in Euthymic Bipolar I Patients with and without Suicide Attempts
Joint Authors
Rocha, Marlos Vasconcelos
Nery-Fernandes, Fabiana
Guimarães, José Luiz
Quarantini, Lucas de Castro
de Oliveira, Irismar Reis
Ladeia-Rocha, Giovanna G.
Jackowski, Andrea Parolin
de Araujo Neto, César
Miranda-Scippa, Ângela
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction/Objective.
Evidence suggests that the prefrontal cortex has been implicated in the pathophysiology of bipolar disorder (BD), but few neurochemical studies have evaluated this region in bipolar patients and there is no information from BD suicide attempters using Proton Magnetic Resonance Spectroscopy (H+MRS).
The objective was to evaluate the metabolic function of the medial orbital frontal cortex in euthymic BD type I suicide and nonsuicide attempters compared to healthy subjects by H+MRS.
Methods.
40 euthymic bipolar I outpatients, 19 without and 21 with history of suicide attempt, and 22 healthy subjects were interviewed using the Structured Clinical Interview with the DSM-IV axis I, the Hamilton Depression Rating Scale, the Young Mania Rating Scale, and the Barratt Impulsiveness Scale-11 and underwent H+MRS.
Results.
We did not find any metabolic abnormality in medial orbital frontal regions of suicide and nonsuicide BD patients and BD patients as a group compared to healthy subjects.
Conclusions.
The combined chronic use of psychotropic drugs with neuroprotective or neurotrophic effects leading to a euthymic state for longer periods of time may improve neurometabolic function, at least measured by H+MRS, even in suicide attempters.
Besides, these results may implicate mood dependent alterations in brain metabolic activity.
However, more studies with larger sample sizes of this heterogeneous disorder are warranted to clarify these data.
American Psychological Association (APA)
Rocha, Marlos Vasconcelos& Nery-Fernandes, Fabiana& Guimarães, José Luiz& Quarantini, Lucas de Castro& de Oliveira, Irismar Reis& Ladeia-Rocha, Giovanna G.…[et al.]. 2015. Normal Metabolic Levels in Prefrontal Cortex in Euthymic Bipolar I Patients with and without Suicide Attempts. Neural Plasticity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075296
Modern Language Association (MLA)
Rocha, Marlos Vasconcelos…[et al.]. Normal Metabolic Levels in Prefrontal Cortex in Euthymic Bipolar I Patients with and without Suicide Attempts. Neural Plasticity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075296
American Medical Association (AMA)
Rocha, Marlos Vasconcelos& Nery-Fernandes, Fabiana& Guimarães, José Luiz& Quarantini, Lucas de Castro& de Oliveira, Irismar Reis& Ladeia-Rocha, Giovanna G.…[et al.]. Normal Metabolic Levels in Prefrontal Cortex in Euthymic Bipolar I Patients with and without Suicide Attempts. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075296