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Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury
المؤلفون المشاركون
Wang, Qun
Sun, Yanyuan
Ren, Yingna
Gao, Yandong
Tian, Li
Liu, Yang
Pu, Yanan
Gou, Xingchun
Chen, Yanke
Lu, Yan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Matrix metalloproteinases (MMPs) are widely implicated in inflammation and tissue remodeling associated with various neurodegenerative diseases and play an important role in nociception and allodynia.
Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) plays a key regulatory role for MMP activities.
However, the role of EMMPRIN in the development of neuropathic pain is not clear.
Western blotting, real-time quantitative RT-PCR (qRT-PCR), and immunofluorescence were performed to determine the changes of messenger RNA and protein of EMMPRIN/OX47 and their cellular localization in the rat dorsal root ganglion (DRG) after nerve injury.
Paw withdrawal threshold test was examined to evaluate the pain behavior in spinal nerve ligation (SNL) model.
The lentivirus containing OX47 shRNA was injected into the DRG one day before SNL.
The expression level of both mRNA and protein of OX47 was markedly upregulated in ipsilateral DRG after SNL.
OX47 was mainly expressed in the extracellular matrix of DRG.
Administration of shRNA targeted against OX47 in vivo remarkably attenuated mechanical allodynia induced by SNL.
In conclusion, peripheral nerve injury induced upregulation of OX47 in the extracellular matrix of DRG.
RNA interference against OX47 significantly suppressed the expression of OX47 mRNA and the development of mechanical allodynia.
The altered expression of OX47 may contribute to the development of neuropathic pain after nerve injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Qun& Sun, Yanyuan& Ren, Yingna& Gao, Yandong& Tian, Li& Liu, Yang…[et al.]. 2015. Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury. Neural Plasticity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075310
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Qun…[et al.]. Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury. Neural Plasticity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075310
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Qun& Sun, Yanyuan& Ren, Yingna& Gao, Yandong& Tian, Li& Liu, Yang…[et al.]. Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075310
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075310
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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