Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder
المؤلفون المشاركون
Zeng, Jinkun
Luo, Qinghua
Du, Lian
Liao, Wei
Li, Yongmei
Liu, Haixia
Liu, Dan
Fu, Yixiao
Qiu, Haitang
Li, Xirong
Qiu, Tian
Meng, Huaqing
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
Electroconvulsive therapy (ECT) is considered one of the most effective and fast-acting treatment options for depressive episodes.
Little is known, however, about ECT’s enabling brain (neuro)plasticity effects, particular for plasticity of white matter pathway.
Materials and Methods.
We collected longitudinal diffusion tensor imaging in the first-episode, drug-naïve major depressive disorder (MDD) patients n=24 before and after a predefined time window ECT treatment.
We constructed large-scale anatomical networks derived from white matter fiber tractography and evaluated the topological reorganization using graph theoretical analysis.
We also assessed the relationship between topological reorganization with improvements in depressive symptoms.
Results.
Our investigation revealed three main findings: (1) the small-worldness was persistent after ECT series; (2) anatomical connections changes were found in limbic structure, temporal and frontal lobes, in which the connection changes between amygdala and parahippocampus correlate with depressive symptom reduction; (3) significant nodal strength changes were found in right paralimbic network.
Conclusions.
ECT elicits neuroplastic processes associated with improvements in depressive symptoms that act to specific local ventral frontolimbic circuits, but not small-world property.
Overall, ECT induced topological reorganization in large-scale brain structural network, opening up new avenues to better understand the mode of ECT action in MDD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zeng, Jinkun& Luo, Qinghua& Du, Lian& Liao, Wei& Li, Yongmei& Liu, Haixia…[et al.]. 2015. Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder. Neural Plasticity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075313
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zeng, Jinkun…[et al.]. Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder. Neural Plasticity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075313
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zeng, Jinkun& Luo, Qinghua& Du, Lian& Liao, Wei& Li, Yongmei& Liu, Haixia…[et al.]. Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075313
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075313
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر