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Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder
Joint Authors
Zeng, Jinkun
Luo, Qinghua
Du, Lian
Liao, Wei
Li, Yongmei
Liu, Haixia
Liu, Dan
Fu, Yixiao
Qiu, Haitang
Li, Xirong
Qiu, Tian
Meng, Huaqing
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Electroconvulsive therapy (ECT) is considered one of the most effective and fast-acting treatment options for depressive episodes.
Little is known, however, about ECT’s enabling brain (neuro)plasticity effects, particular for plasticity of white matter pathway.
Materials and Methods.
We collected longitudinal diffusion tensor imaging in the first-episode, drug-naïve major depressive disorder (MDD) patients n=24 before and after a predefined time window ECT treatment.
We constructed large-scale anatomical networks derived from white matter fiber tractography and evaluated the topological reorganization using graph theoretical analysis.
We also assessed the relationship between topological reorganization with improvements in depressive symptoms.
Results.
Our investigation revealed three main findings: (1) the small-worldness was persistent after ECT series; (2) anatomical connections changes were found in limbic structure, temporal and frontal lobes, in which the connection changes between amygdala and parahippocampus correlate with depressive symptom reduction; (3) significant nodal strength changes were found in right paralimbic network.
Conclusions.
ECT elicits neuroplastic processes associated with improvements in depressive symptoms that act to specific local ventral frontolimbic circuits, but not small-world property.
Overall, ECT induced topological reorganization in large-scale brain structural network, opening up new avenues to better understand the mode of ECT action in MDD.
American Psychological Association (APA)
Zeng, Jinkun& Luo, Qinghua& Du, Lian& Liao, Wei& Li, Yongmei& Liu, Haixia…[et al.]. 2015. Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder. Neural Plasticity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075313
Modern Language Association (MLA)
Zeng, Jinkun…[et al.]. Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder. Neural Plasticity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075313
American Medical Association (AMA)
Zeng, Jinkun& Luo, Qinghua& Du, Lian& Liao, Wei& Li, Yongmei& Liu, Haixia…[et al.]. Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075313