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Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity
المؤلفون المشاركون
Bazovkina, Darya V.
Kondaurova, Elena M.
Naumenko, Vladimir S.
Ponimaskin, Evgeni
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In the present study behavioral effects of the 5-HT2C serotonin receptor were investigated in different mouse strains.
The 5-HT2C receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice.
This effect was receptor-specific because it was inhibited by the 5-HT2C receptor antagonist RS102221.
To study the role of genotype in 5-HT2C receptor-induced hypolocomotion, locomotor activity of seven inbred mouse strains was measured after MK-212 acute treatment.
We found that the 5-HT2C receptor stimulation by MK-212 decreased distance traveled in the open field test in CBA/Lac, C57Bl/6, C3H/He, and ICR mice, whereas it failed to affect locomotor activity in DBA/2J, Asn, and Balb/c mice.
We also compared the interstrain differences in functional response to 5-HT2C and 5-HT2A receptors activation measured by the quantification of receptor-mediated head-twitches.
These experiments revealed significant positive correlation between 5-HT2C and 5-HT2A receptors functional responses for all investigated mouse strains.
Moreover, we found that 5-HT2A receptor activation with DOI did not change locomotor activity in CBA/Lac mice.
Taken together, our data indicate the implication of 5-HT2C receptors in regulation of locomotor activity and suggest the shared mechanism for functional responses mediated by 5-HT2C and 5-HT2A receptors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bazovkina, Darya V.& Kondaurova, Elena M.& Naumenko, Vladimir S.& Ponimaskin, Evgeni. 2015. Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity. Neural Plasticity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075418
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bazovkina, Darya V.…[et al.]. Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity. Neural Plasticity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075418
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bazovkina, Darya V.& Kondaurova, Elena M.& Naumenko, Vladimir S.& Ponimaskin, Evgeni. Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075418
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075418
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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