Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity
Joint Authors
Bazovkina, Darya V.
Kondaurova, Elena M.
Naumenko, Vladimir S.
Ponimaskin, Evgeni
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In the present study behavioral effects of the 5-HT2C serotonin receptor were investigated in different mouse strains.
The 5-HT2C receptor agonist MK-212 applied intraperitoneally induced significant dose-dependent reduction of distance traveled in the open field test in CBA/Lac mice.
This effect was receptor-specific because it was inhibited by the 5-HT2C receptor antagonist RS102221.
To study the role of genotype in 5-HT2C receptor-induced hypolocomotion, locomotor activity of seven inbred mouse strains was measured after MK-212 acute treatment.
We found that the 5-HT2C receptor stimulation by MK-212 decreased distance traveled in the open field test in CBA/Lac, C57Bl/6, C3H/He, and ICR mice, whereas it failed to affect locomotor activity in DBA/2J, Asn, and Balb/c mice.
We also compared the interstrain differences in functional response to 5-HT2C and 5-HT2A receptors activation measured by the quantification of receptor-mediated head-twitches.
These experiments revealed significant positive correlation between 5-HT2C and 5-HT2A receptors functional responses for all investigated mouse strains.
Moreover, we found that 5-HT2A receptor activation with DOI did not change locomotor activity in CBA/Lac mice.
Taken together, our data indicate the implication of 5-HT2C receptors in regulation of locomotor activity and suggest the shared mechanism for functional responses mediated by 5-HT2C and 5-HT2A receptors.
American Psychological Association (APA)
Bazovkina, Darya V.& Kondaurova, Elena M.& Naumenko, Vladimir S.& Ponimaskin, Evgeni. 2015. Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity. Neural Plasticity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075418
Modern Language Association (MLA)
Bazovkina, Darya V.…[et al.]. Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity. Neural Plasticity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075418
American Medical Association (AMA)
Bazovkina, Darya V.& Kondaurova, Elena M.& Naumenko, Vladimir S.& Ponimaskin, Evgeni. Genotype-Dependent Difference in 5-HT2C Receptor-Induced Hypolocomotion: Comparison with 5-HT2A Receptor Functional Activity. Neural Plasticity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075418