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Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury
المؤلفون المشاركون
Chen, Xing
Liu, Qi
Wang, Dawei
Feng, Shihai
Zhao, Yongjian
Shi, Yun
Liu, Qun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To explore the protective effects of hydrogen-rich saline on rats with smoke inhalation injury.
Methods.
36 healthy male Sprague-Dawley rats were randomly divided into 3 groups (n=12 per group): sham group (S), inhalation injury plus normal saline treatment group (I+NS), and inhalation injury plus hydrogen-rich saline treatment group (I+HS).
30 min after injury, normal saline and hydrogen-rich saline were injected intraperitoneally (5 mL/kg) in I+NS group and I+HS group, respectively.
All rats were euthanized and blood and organ specimens were collected for determination 24 h after inhalation injury.
Results.
Tumor necrosis factor-alpha (TNF-α) levels, malondialdehyde (MDA) concentrations, nuclear factor kappa B (NF-κB) p65 expression, and apoptosis index (AI) in I+HS group were significantly decreased (P<0.05), while superoxide dismutase (SOD) activities were increased compared with those in I+NS group; and a marked improvement in alveolar structure was also found after hydrogen-rich saline treatment.
Conclusions.
Hydrogen-rich saline treatment exerts protective effects in acute lung injury induced by inhalation injury, at least in part through the activation of anti-inflammatory and antioxidant pathways and inhibition of apoptosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Xing& Liu, Qi& Wang, Dawei& Feng, Shihai& Zhao, Yongjian& Shi, Yun…[et al.]. 2015. Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075524
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Xing…[et al.]. Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075524
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Xing& Liu, Qi& Wang, Dawei& Feng, Shihai& Zhao, Yongjian& Shi, Yun…[et al.]. Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075524
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075524
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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