Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury
Joint Authors
Chen, Xing
Liu, Qi
Wang, Dawei
Feng, Shihai
Zhao, Yongjian
Shi, Yun
Liu, Qun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To explore the protective effects of hydrogen-rich saline on rats with smoke inhalation injury.
Methods.
36 healthy male Sprague-Dawley rats were randomly divided into 3 groups (n=12 per group): sham group (S), inhalation injury plus normal saline treatment group (I+NS), and inhalation injury plus hydrogen-rich saline treatment group (I+HS).
30 min after injury, normal saline and hydrogen-rich saline were injected intraperitoneally (5 mL/kg) in I+NS group and I+HS group, respectively.
All rats were euthanized and blood and organ specimens were collected for determination 24 h after inhalation injury.
Results.
Tumor necrosis factor-alpha (TNF-α) levels, malondialdehyde (MDA) concentrations, nuclear factor kappa B (NF-κB) p65 expression, and apoptosis index (AI) in I+HS group were significantly decreased (P<0.05), while superoxide dismutase (SOD) activities were increased compared with those in I+NS group; and a marked improvement in alveolar structure was also found after hydrogen-rich saline treatment.
Conclusions.
Hydrogen-rich saline treatment exerts protective effects in acute lung injury induced by inhalation injury, at least in part through the activation of anti-inflammatory and antioxidant pathways and inhibition of apoptosis.
American Psychological Association (APA)
Chen, Xing& Liu, Qi& Wang, Dawei& Feng, Shihai& Zhao, Yongjian& Shi, Yun…[et al.]. 2015. Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075524
Modern Language Association (MLA)
Chen, Xing…[et al.]. Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075524
American Medical Association (AMA)
Chen, Xing& Liu, Qi& Wang, Dawei& Feng, Shihai& Zhao, Yongjian& Shi, Yun…[et al.]. Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075524