CO2 Pneumoperitoneum Preserves β-Arrestin 2 Content and Reduces High Mobility Group Box-1 (HMGB-1) Expression in an Animal Model of Peritonitis
المؤلفون المشاركون
Bitto, Alessandra
Romeo, Carmelo
Pizzino, Gabriele
Irrera, Natasha
Montalto, Angela Simona
Impellizzeri, Pietro
Costa, Gaetano
Minutoli, Letteria
Squadrito, Francesco
Altavilla, Domenica
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Laparoscopy (LS) has been shown to decrease the inflammatory sequelae of endotoxemia.
β-arrestin 2 plays an important function in signal transduction pathway of TLR4.
High mobility group box-1 (HMGB-1) is involved in the delayed systemic inflammatory response.
We investigated the effects of CO2 insufflation on liver, lung, and kidney expression of both β-arrestin 2 and HMGB-1 during sepsis.
Cecal ligation and puncture (CLP) was performed in male rats and 6 h later the animals were randomly assigned to receive a CO2 pneumoperitoneum or laparotomy.
Animals were euthanized; liver, lung, and kidney were removed for the evaluation of β-arrestin 2 and HMGB-1 expression.
Immunohistochemical detection of myeloperoxidase (MPO) was investigated in lung and liver and bacterial load was determined in the peritoneal fluid.
CO2 pneumoperitoneum reduced peritoneal bacterial load, increased the expression of β-arrestin 2, and blunted the expression of the potent proinflammatory HMGB-1 in liver, lung, and kidney compared with laparotomy.
Liver and lung MPO was markedly reduced in rats subjected to LS compared with laparotomy.
We believe that CO2 exerts an early protective effect by reducing bacterial load and likely toll-like receptor activation which in turn leads to a preserved β-arrestin 2 expression and a reduced HMGB-1 expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Montalto, Angela Simona& Bitto, Alessandra& Minutoli, Letteria& Impellizzeri, Pietro& Costa, Gaetano& Irrera, Natasha…[et al.]. 2015. CO2 Pneumoperitoneum Preserves β-Arrestin 2 Content and Reduces High Mobility Group Box-1 (HMGB-1) Expression in an Animal Model of Peritonitis. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075539
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Montalto, Angela Simona…[et al.]. CO2 Pneumoperitoneum Preserves β-Arrestin 2 Content and Reduces High Mobility Group Box-1 (HMGB-1) Expression in an Animal Model of Peritonitis. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075539
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Montalto, Angela Simona& Bitto, Alessandra& Minutoli, Letteria& Impellizzeri, Pietro& Costa, Gaetano& Irrera, Natasha…[et al.]. CO2 Pneumoperitoneum Preserves β-Arrestin 2 Content and Reduces High Mobility Group Box-1 (HMGB-1) Expression in an Animal Model of Peritonitis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075539
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075539
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر