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Metallothionein-III Knockout Mice Aggravate Mitochondrial Superoxide Production and Peroxiredoxin 3 Expression in Thyroid after Excessive Iodide Exposure
المؤلفون المشاركون
Wang, Lingyan
Duan, Qi
Wang, Tingting
Ahmed, Mohamed
Zhang, Na
Yao, Xiaomei
Lin, Laixiang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Purpose.
We aim to figure out the effect of metallothioneins on iodide excess induced oxidative stress in the thyroid.
Methods.
Eight-week-old MT-I/II knockout (MT-I/II KO) mice and background-matched wild-type (WT) mice were used.
Mitochondrial superoxide production and peroxiredoxin (Prx) 3 expression were measured.
Results.
In in vitro study, more significant increases in mitochondrial superoxide production and Prx 3 expression were detected in the MT-I/II KO groups.
In in vivo study, significantly higher concentrations of urinary iodine level were detected in MT-I/II KO mice in 100 HI group.
Compared to the NI group, there was no significant difference existing in serum thyroid hormones level in either groups (P>0.05), while the mitochondrial superoxide production was significantly increased in 100 HI groups with significantly increased LDH activity and decreased relative cell viability.
Compared to WT mice, more significant changes were detected in MT-I/II KO mice in 100 HI groups.
No significant differences were detected between the NI group and 10 HI group in both the MT-I/II KO and WT mice groups (P>0.05).
Conclusions.
Iodide excess in a thyroid without MT I/II protection may result in strong mitochondrial oxidative stress, which further leads to the damage of thyrocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Na& Wang, Lingyan& Duan, Qi& Lin, Laixiang& Ahmed, Mohamed& Wang, Tingting…[et al.]. 2015. Metallothionein-III Knockout Mice Aggravate Mitochondrial Superoxide Production and Peroxiredoxin 3 Expression in Thyroid after Excessive Iodide Exposure. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075575
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Na…[et al.]. Metallothionein-III Knockout Mice Aggravate Mitochondrial Superoxide Production and Peroxiredoxin 3 Expression in Thyroid after Excessive Iodide Exposure. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075575
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Na& Wang, Lingyan& Duan, Qi& Lin, Laixiang& Ahmed, Mohamed& Wang, Tingting…[et al.]. Metallothionein-III Knockout Mice Aggravate Mitochondrial Superoxide Production and Peroxiredoxin 3 Expression in Thyroid after Excessive Iodide Exposure. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075575
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075575
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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