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Metallothionein-III Knockout Mice Aggravate Mitochondrial Superoxide Production and Peroxiredoxin 3 Expression in Thyroid after Excessive Iodide Exposure
Joint Authors
Wang, Lingyan
Duan, Qi
Wang, Tingting
Ahmed, Mohamed
Zhang, Na
Yao, Xiaomei
Lin, Laixiang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
We aim to figure out the effect of metallothioneins on iodide excess induced oxidative stress in the thyroid.
Methods.
Eight-week-old MT-I/II knockout (MT-I/II KO) mice and background-matched wild-type (WT) mice were used.
Mitochondrial superoxide production and peroxiredoxin (Prx) 3 expression were measured.
Results.
In in vitro study, more significant increases in mitochondrial superoxide production and Prx 3 expression were detected in the MT-I/II KO groups.
In in vivo study, significantly higher concentrations of urinary iodine level were detected in MT-I/II KO mice in 100 HI group.
Compared to the NI group, there was no significant difference existing in serum thyroid hormones level in either groups (P>0.05), while the mitochondrial superoxide production was significantly increased in 100 HI groups with significantly increased LDH activity and decreased relative cell viability.
Compared to WT mice, more significant changes were detected in MT-I/II KO mice in 100 HI groups.
No significant differences were detected between the NI group and 10 HI group in both the MT-I/II KO and WT mice groups (P>0.05).
Conclusions.
Iodide excess in a thyroid without MT I/II protection may result in strong mitochondrial oxidative stress, which further leads to the damage of thyrocytes.
American Psychological Association (APA)
Zhang, Na& Wang, Lingyan& Duan, Qi& Lin, Laixiang& Ahmed, Mohamed& Wang, Tingting…[et al.]. 2015. Metallothionein-III Knockout Mice Aggravate Mitochondrial Superoxide Production and Peroxiredoxin 3 Expression in Thyroid after Excessive Iodide Exposure. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075575
Modern Language Association (MLA)
Zhang, Na…[et al.]. Metallothionein-III Knockout Mice Aggravate Mitochondrial Superoxide Production and Peroxiredoxin 3 Expression in Thyroid after Excessive Iodide Exposure. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075575
American Medical Association (AMA)
Zhang, Na& Wang, Lingyan& Duan, Qi& Lin, Laixiang& Ahmed, Mohamed& Wang, Tingting…[et al.]. Metallothionein-III Knockout Mice Aggravate Mitochondrial Superoxide Production and Peroxiredoxin 3 Expression in Thyroid after Excessive Iodide Exposure. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075575