Cardiac and Vascular Synergic Protective Effect of Olea europea L. Leaves and Hibiscus sabdariffa L. Flower Extracts
المؤلفون المشاركون
Micucci, Matteo
Chiarini, Alberto
Budriesi, Roberta
Di Lecce, Giuseppe
Aldini, Rita
Angeletti, Andrea
Malaguti, Marco
Gallina Toschi, Tullia
Hrelia, Silvana
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-09
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
This study was aimed at investigating the cardiovascular effects of an Olea europea L.
leaf extract (OEE), of a Hibiscus sabdariffa L.
flower extract (HSE), and of their 13 : 2 w/w mixture in order to assess their cardiac and vascular activity.
Both extracts were fully characterized in their bioactive compounds by HPLC-MS/MS analysis.
The study was performed using primary vascular endothelial cells (HUVECs) to investigate the antioxidant and cytoprotective effect of the extracts and their mixture and isolated guinea-pig left and right atria and aorta to evaluate the inotropic and chronotropic activities and vasorelaxant properties.
In cultured HUVECs, OEE and HSE reduced intracellular reactive oxygen species formation and improved cell viability, following oxidative stress in dose-dependent manner.
OEE and HSE exerted negative inotropic and vasorelaxant effects without any chronotropic property.
Interestingly, the mixture exerted higher cytoprotective effects and antioxidant activities.
Moreover, the mixture exerted an inotropic effect similar to each single extract, while it revealed an intrinsic negative chronotropic activity different from the single extract; its relaxant activity was higher than that of each single extract.
In conclusion OEE and HSE mixture has a good potential for pharmaceutical and nutraceutical application, thanks to the synergistic effects of the single phytochemicals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Micucci, Matteo& Malaguti, Marco& Gallina Toschi, Tullia& Di Lecce, Giuseppe& Aldini, Rita& Angeletti, Andrea…[et al.]. 2015. Cardiac and Vascular Synergic Protective Effect of Olea europea L. Leaves and Hibiscus sabdariffa L. Flower Extracts. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075588
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Micucci, Matteo…[et al.]. Cardiac and Vascular Synergic Protective Effect of Olea europea L. Leaves and Hibiscus sabdariffa L. Flower Extracts. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1075588
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Micucci, Matteo& Malaguti, Marco& Gallina Toschi, Tullia& Di Lecce, Giuseppe& Aldini, Rita& Angeletti, Andrea…[et al.]. Cardiac and Vascular Synergic Protective Effect of Olea europea L. Leaves and Hibiscus sabdariffa L. Flower Extracts. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075588
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075588
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر