Cardiac and Vascular Synergic Protective Effect of Olea europea L. Leaves and Hibiscus sabdariffa L. Flower Extracts
Joint Authors
Micucci, Matteo
Chiarini, Alberto
Budriesi, Roberta
Di Lecce, Giuseppe
Aldini, Rita
Angeletti, Andrea
Malaguti, Marco
Gallina Toschi, Tullia
Hrelia, Silvana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
This study was aimed at investigating the cardiovascular effects of an Olea europea L.
leaf extract (OEE), of a Hibiscus sabdariffa L.
flower extract (HSE), and of their 13 : 2 w/w mixture in order to assess their cardiac and vascular activity.
Both extracts were fully characterized in their bioactive compounds by HPLC-MS/MS analysis.
The study was performed using primary vascular endothelial cells (HUVECs) to investigate the antioxidant and cytoprotective effect of the extracts and their mixture and isolated guinea-pig left and right atria and aorta to evaluate the inotropic and chronotropic activities and vasorelaxant properties.
In cultured HUVECs, OEE and HSE reduced intracellular reactive oxygen species formation and improved cell viability, following oxidative stress in dose-dependent manner.
OEE and HSE exerted negative inotropic and vasorelaxant effects without any chronotropic property.
Interestingly, the mixture exerted higher cytoprotective effects and antioxidant activities.
Moreover, the mixture exerted an inotropic effect similar to each single extract, while it revealed an intrinsic negative chronotropic activity different from the single extract; its relaxant activity was higher than that of each single extract.
In conclusion OEE and HSE mixture has a good potential for pharmaceutical and nutraceutical application, thanks to the synergistic effects of the single phytochemicals.
American Psychological Association (APA)
Micucci, Matteo& Malaguti, Marco& Gallina Toschi, Tullia& Di Lecce, Giuseppe& Aldini, Rita& Angeletti, Andrea…[et al.]. 2015. Cardiac and Vascular Synergic Protective Effect of Olea europea L. Leaves and Hibiscus sabdariffa L. Flower Extracts. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075588
Modern Language Association (MLA)
Micucci, Matteo…[et al.]. Cardiac and Vascular Synergic Protective Effect of Olea europea L. Leaves and Hibiscus sabdariffa L. Flower Extracts. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1075588
American Medical Association (AMA)
Micucci, Matteo& Malaguti, Marco& Gallina Toschi, Tullia& Di Lecce, Giuseppe& Aldini, Rita& Angeletti, Andrea…[et al.]. Cardiac and Vascular Synergic Protective Effect of Olea europea L. Leaves and Hibiscus sabdariffa L. Flower Extracts. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075588