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Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study
المؤلفون المشاركون
Adem, Abdu
Ojha, Shreesh
Nurulain, Syed M.
Tekes, Kornelia
Shafiullah, Mohammad
Kalasz, Huba
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
There are a great number of reports with assertions that oxidative stress is produced by organophosphorus compound (OPC) poisoning and is a cofactor of mortality and morbidity in OPC toxicity.
In addition, antioxidants have been suggested as adjuncts to standard therapy.
However, there is no substantial evidence for the benefit of the use of antioxidants in survival after acute intoxication of OPCs.
The present study was conducted to assess the effectiveness of three non-enzymatic antioxidants (NEAOs), N-acetylcysteine (NAC), glutathione (GSH), and ascorbic acid (AA), in acute intoxication of adult male Wister rats with paraoxon.
The efficacy of the antioxidants was estimated as both a pretreatment and a concurrent application along with the standard oxime, pralidoxime (2-PAM).
Relative risk of death after 48 hours of application was estimated by Cox regression analysis.
The results revealed no benefit of either tested NEAO to the improvement in survival of experimental rats.
The application of these antioxidants was found to be deleterious when administered along with pralidoxime compared to the treatment with pralidoxime alone.
It has been concluded that the tested non-enzymatic antioxidants are not useful in acute toxicity for improving survival rates.
However, the individual toxic dynamics of diversified OPCs should not be overlooked and further studies with different OPCs are suggested.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nurulain, Syed M.& Ojha, Shreesh& Tekes, Kornelia& Shafiullah, Mohammad& Kalasz, Huba& Adem, Abdu. 2015. Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075591
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nurulain, Syed M.…[et al.]. Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1075591
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nurulain, Syed M.& Ojha, Shreesh& Tekes, Kornelia& Shafiullah, Mohammad& Kalasz, Huba& Adem, Abdu. Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075591
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075591
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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