Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study
Joint Authors
Adem, Abdu
Ojha, Shreesh
Nurulain, Syed M.
Tekes, Kornelia
Shafiullah, Mohammad
Kalasz, Huba
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
There are a great number of reports with assertions that oxidative stress is produced by organophosphorus compound (OPC) poisoning and is a cofactor of mortality and morbidity in OPC toxicity.
In addition, antioxidants have been suggested as adjuncts to standard therapy.
However, there is no substantial evidence for the benefit of the use of antioxidants in survival after acute intoxication of OPCs.
The present study was conducted to assess the effectiveness of three non-enzymatic antioxidants (NEAOs), N-acetylcysteine (NAC), glutathione (GSH), and ascorbic acid (AA), in acute intoxication of adult male Wister rats with paraoxon.
The efficacy of the antioxidants was estimated as both a pretreatment and a concurrent application along with the standard oxime, pralidoxime (2-PAM).
Relative risk of death after 48 hours of application was estimated by Cox regression analysis.
The results revealed no benefit of either tested NEAO to the improvement in survival of experimental rats.
The application of these antioxidants was found to be deleterious when administered along with pralidoxime compared to the treatment with pralidoxime alone.
It has been concluded that the tested non-enzymatic antioxidants are not useful in acute toxicity for improving survival rates.
However, the individual toxic dynamics of diversified OPCs should not be overlooked and further studies with different OPCs are suggested.
American Psychological Association (APA)
Nurulain, Syed M.& Ojha, Shreesh& Tekes, Kornelia& Shafiullah, Mohammad& Kalasz, Huba& Adem, Abdu. 2015. Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075591
Modern Language Association (MLA)
Nurulain, Syed M.…[et al.]. Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1075591
American Medical Association (AMA)
Nurulain, Syed M.& Ojha, Shreesh& Tekes, Kornelia& Shafiullah, Mohammad& Kalasz, Huba& Adem, Abdu. Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075591