Nephroprotective Effects of Polydatin against IschemiaReperfusion Injury: A Role for the PI3KAkt Signal Pathway
المؤلفون المشاركون
Liu, Hong-Bao
Meng, Qiu-Hong
Huang, Chen
Wang, Jian-Bo
Liu, Xiao-Wei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-20
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Oxidative stress and inflammation are involved in the pathogenesis in renal ischemia/reperfusion (I/R) injury.
It has been demonstrated that polydatin processed the antioxidative, anti-inflammatory, and nephroprotective properties.
However, whether it has beneficial effects and the possible mechanisms on renal I/R injury remain unclear.
In our present study I/R models were simulated both in vitro and in vivo.
Compared with vehicle control, the administration of polydatin significantly improved the renal function, accelerated the mitogenic response and reduced cell apoptosis in renal I/R injury models, strongly suppressed the I/R-induced upregulation of the expression of tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2, inducible nitric oxide synthase, prostaglandin E-2, and nitric oxide levels, and dramatically decreased contents of malondialdehyde, but it increased the activity of superoxide dismutase, glutathione transferase, glutathione peroxidase and catalase, and the level of glutathione.
Further investigation showed that polydatin upregulated the phosphorylation of Akt in kidneys of I/R injury dose-dependently.
However, all beneficial effects of polydatin mentioned above were counteracted when we inhibited PI3K/Akt pathway with its specific inhibitor, wortmannin.
Taken together, the present findings provide the first evidence demonstrating that PD exhibited prominent nephroprotective effects against renal I/R injury by antioxidative stress and inflammation through PI3-K/Akt-dependent molecular mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Hong-Bao& Meng, Qiu-Hong& Huang, Chen& Wang, Jian-Bo& Liu, Xiao-Wei. 2015. Nephroprotective Effects of Polydatin against IschemiaReperfusion Injury: A Role for the PI3KAkt Signal Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075603
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Hong-Bao…[et al.]. Nephroprotective Effects of Polydatin against IschemiaReperfusion Injury: A Role for the PI3KAkt Signal Pathway. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075603
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Hong-Bao& Meng, Qiu-Hong& Huang, Chen& Wang, Jian-Bo& Liu, Xiao-Wei. Nephroprotective Effects of Polydatin against IschemiaReperfusion Injury: A Role for the PI3KAkt Signal Pathway. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075603
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075603
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر