Nephroprotective Effects of Polydatin against IschemiaReperfusion Injury: A Role for the PI3KAkt Signal Pathway
Joint Authors
Liu, Hong-Bao
Meng, Qiu-Hong
Huang, Chen
Wang, Jian-Bo
Liu, Xiao-Wei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Oxidative stress and inflammation are involved in the pathogenesis in renal ischemia/reperfusion (I/R) injury.
It has been demonstrated that polydatin processed the antioxidative, anti-inflammatory, and nephroprotective properties.
However, whether it has beneficial effects and the possible mechanisms on renal I/R injury remain unclear.
In our present study I/R models were simulated both in vitro and in vivo.
Compared with vehicle control, the administration of polydatin significantly improved the renal function, accelerated the mitogenic response and reduced cell apoptosis in renal I/R injury models, strongly suppressed the I/R-induced upregulation of the expression of tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2, inducible nitric oxide synthase, prostaglandin E-2, and nitric oxide levels, and dramatically decreased contents of malondialdehyde, but it increased the activity of superoxide dismutase, glutathione transferase, glutathione peroxidase and catalase, and the level of glutathione.
Further investigation showed that polydatin upregulated the phosphorylation of Akt in kidneys of I/R injury dose-dependently.
However, all beneficial effects of polydatin mentioned above were counteracted when we inhibited PI3K/Akt pathway with its specific inhibitor, wortmannin.
Taken together, the present findings provide the first evidence demonstrating that PD exhibited prominent nephroprotective effects against renal I/R injury by antioxidative stress and inflammation through PI3-K/Akt-dependent molecular mechanisms.
American Psychological Association (APA)
Liu, Hong-Bao& Meng, Qiu-Hong& Huang, Chen& Wang, Jian-Bo& Liu, Xiao-Wei. 2015. Nephroprotective Effects of Polydatin against IschemiaReperfusion Injury: A Role for the PI3KAkt Signal Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075603
Modern Language Association (MLA)
Liu, Hong-Bao…[et al.]. Nephroprotective Effects of Polydatin against IschemiaReperfusion Injury: A Role for the PI3KAkt Signal Pathway. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075603
American Medical Association (AMA)
Liu, Hong-Bao& Meng, Qiu-Hong& Huang, Chen& Wang, Jian-Bo& Liu, Xiao-Wei. Nephroprotective Effects of Polydatin against IschemiaReperfusion Injury: A Role for the PI3KAkt Signal Pathway. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075603