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Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells
المؤلفون المشاركون
Dando, Ilaria
Cordani, Marco
Dalla Pozza, Elisa
Biondani, Giulia
Donadelli, Massimo
Palmieri, Marta
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-29
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Increasing evidence indicates that most of the tumors are sustained by a distinct population of cancer stem cells (CSCs), which are responsible for growth, metastasis, invasion, and recurrence.
CSCs are typically characterized by self-renewal, the key biological process allowing continuous tumor proliferation, as well as by differentiation potential, which leads to the formation of the bulk of the tumor mass.
CSCs have several advantages over the differentiated cancer cell populations, including the resistance to radio- and chemotherapy, and their gene-expression programs have been shown to correlate with poor clinical outcome, further supporting the relevance of stemness properties in cancer.
The observation that CSCs possess enhanced mechanisms of protection from reactive oxygen species (ROS) induced stress and a different metabolism from the differentiated part of the tumor has paved the way to develop drugs targeting CSC specific signaling.
In this review, we describe the role of ROS and of ROS-related microRNAs in the establishment and maintenance of self-renewal and differentiation capacities of CSCs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dando, Ilaria& Cordani, Marco& Dalla Pozza, Elisa& Biondani, Giulia& Donadelli, Massimo& Palmieri, Marta. 2015. Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075648
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dando, Ilaria…[et al.]. Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075648
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dando, Ilaria& Cordani, Marco& Dalla Pozza, Elisa& Biondani, Giulia& Donadelli, Massimo& Palmieri, Marta. Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075648
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075648
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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