Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells
Joint Authors
Dando, Ilaria
Cordani, Marco
Dalla Pozza, Elisa
Biondani, Giulia
Donadelli, Massimo
Palmieri, Marta
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Increasing evidence indicates that most of the tumors are sustained by a distinct population of cancer stem cells (CSCs), which are responsible for growth, metastasis, invasion, and recurrence.
CSCs are typically characterized by self-renewal, the key biological process allowing continuous tumor proliferation, as well as by differentiation potential, which leads to the formation of the bulk of the tumor mass.
CSCs have several advantages over the differentiated cancer cell populations, including the resistance to radio- and chemotherapy, and their gene-expression programs have been shown to correlate with poor clinical outcome, further supporting the relevance of stemness properties in cancer.
The observation that CSCs possess enhanced mechanisms of protection from reactive oxygen species (ROS) induced stress and a different metabolism from the differentiated part of the tumor has paved the way to develop drugs targeting CSC specific signaling.
In this review, we describe the role of ROS and of ROS-related microRNAs in the establishment and maintenance of self-renewal and differentiation capacities of CSCs.
American Psychological Association (APA)
Dando, Ilaria& Cordani, Marco& Dalla Pozza, Elisa& Biondani, Giulia& Donadelli, Massimo& Palmieri, Marta. 2015. Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075648
Modern Language Association (MLA)
Dando, Ilaria…[et al.]. Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1075648
American Medical Association (AMA)
Dando, Ilaria& Cordani, Marco& Dalla Pozza, Elisa& Biondani, Giulia& Donadelli, Massimo& Palmieri, Marta. Antioxidant Mechanisms and ROS-Related MicroRNAs in Cancer Stem Cells. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1075648
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075648