Endogenous Estrogen-Mediated Heme Oxygenase Regulation in Experimental Menopause
المؤلفون المشاركون
Varga, Csaba
Gyöngyösi, Mariann
Baráth, Zoltán
Csonka, Anett
Veszelka, Médea
László, Ferenc
Ménesi, Rudolf
Kupai, Krisztina
Berkó, Anikó
Pósa, Anikó
Szabó, Renáta
Pávó, Imre
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Estrogen deficiency is one of the main causes of age-associated diseases in the cardiovascular system.
Female Wistar rats were divided into four experimental groups: pharmacologically ovariectomized, surgically ovariectomized, and 24-month-old intact aging animals were compared with a control group.
The activity and expression of heme oxygenases (HO) in the cardiac left ventricle, the concentrations of cardiac interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), the myeloperoxidase (MPO) activity in the cardiac left ventricle, and the effects of heme oxygenase blockade (by 24-hour and 1-hour pretreatment with tin-protoporphyrin IX, SnPP) on the epinephrine and phentolamine-induced electrocardiogram ST segment changes in vivo were investigated.
The cardiac HO activity and the expression of HO-1 and HO-2 were significantly decreased in the aged rats and after ovariectomy.
Estrogen depletion was accompanied by significant increases in the expression of IL-6 and TNF-α.
The aged and ovariectomized animals exhibited a significantly elevated MPO activity and a significant ST segment depression.
After pretreatment with SnPP augmented ST segment changes were determined.
These findings demonstrate that the sensitivity to cardiac ischemia in estrogen depletion models is associated with suppression of the activity and expression of the HO system and increases in the secretion of proinflammatory cytokines and biomarkers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pósa, Anikó& Szabó, Renáta& Csonka, Anett& Veszelka, Médea& Berkó, Anikó& Baráth, Zoltán…[et al.]. 2015. Endogenous Estrogen-Mediated Heme Oxygenase Regulation in Experimental Menopause. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075651
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pósa, Anikó…[et al.]. Endogenous Estrogen-Mediated Heme Oxygenase Regulation in Experimental Menopause. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075651
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pósa, Anikó& Szabó, Renáta& Csonka, Anett& Veszelka, Médea& Berkó, Anikó& Baráth, Zoltán…[et al.]. Endogenous Estrogen-Mediated Heme Oxygenase Regulation in Experimental Menopause. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075651
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075651
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر