Endogenous Estrogen-Mediated Heme Oxygenase Regulation in Experimental Menopause
Joint Authors
Varga, Csaba
Gyöngyösi, Mariann
Baráth, Zoltán
Csonka, Anett
Veszelka, Médea
László, Ferenc
Ménesi, Rudolf
Kupai, Krisztina
Berkó, Anikó
Pósa, Anikó
Szabó, Renáta
Pávó, Imre
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Estrogen deficiency is one of the main causes of age-associated diseases in the cardiovascular system.
Female Wistar rats were divided into four experimental groups: pharmacologically ovariectomized, surgically ovariectomized, and 24-month-old intact aging animals were compared with a control group.
The activity and expression of heme oxygenases (HO) in the cardiac left ventricle, the concentrations of cardiac interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), the myeloperoxidase (MPO) activity in the cardiac left ventricle, and the effects of heme oxygenase blockade (by 24-hour and 1-hour pretreatment with tin-protoporphyrin IX, SnPP) on the epinephrine and phentolamine-induced electrocardiogram ST segment changes in vivo were investigated.
The cardiac HO activity and the expression of HO-1 and HO-2 were significantly decreased in the aged rats and after ovariectomy.
Estrogen depletion was accompanied by significant increases in the expression of IL-6 and TNF-α.
The aged and ovariectomized animals exhibited a significantly elevated MPO activity and a significant ST segment depression.
After pretreatment with SnPP augmented ST segment changes were determined.
These findings demonstrate that the sensitivity to cardiac ischemia in estrogen depletion models is associated with suppression of the activity and expression of the HO system and increases in the secretion of proinflammatory cytokines and biomarkers.
American Psychological Association (APA)
Pósa, Anikó& Szabó, Renáta& Csonka, Anett& Veszelka, Médea& Berkó, Anikó& Baráth, Zoltán…[et al.]. 2015. Endogenous Estrogen-Mediated Heme Oxygenase Regulation in Experimental Menopause. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075651
Modern Language Association (MLA)
Pósa, Anikó…[et al.]. Endogenous Estrogen-Mediated Heme Oxygenase Regulation in Experimental Menopause. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075651
American Medical Association (AMA)
Pósa, Anikó& Szabó, Renáta& Csonka, Anett& Veszelka, Médea& Berkó, Anikó& Baráth, Zoltán…[et al.]. Endogenous Estrogen-Mediated Heme Oxygenase Regulation in Experimental Menopause. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075651