Xanthine Oxidase Inhibitor, Allopurinol, Prevented Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Aged Rats
المؤلفون المشاركون
Sagor, Md Abu Taher
Tabassum, Nabila
Potol, Md. Abdullah
Alam, Md. Ashraful
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We evaluated the preventive effect of allopurinol on isoproterenol (ISO) induced myocardial infarction in aged rats.
Twelve- to fourteen-month-old male Long Evans rats were divided into three groups: control, ISO, and ISO + allopurinol.
At the end of the study, all rats were sacrificed for blood and organ sample collection to evaluate biochemical parameters and oxidative stress markers analyses.
Histopathological examinations were also conducted to assess inflammatory cell infiltration and fibrosis in heart and kidneys.
Our investigation revealed that the levels of oxidative stress markers were significantly increased while the level of cellular antioxidants, catalase activity, and glutathione concentration in ISO induced rats decreased.
Treatment with allopurinol to ISO induced rats prevented the elevated activities of AST, ALT, and ALP enzymes, and the levels of lipid peroxidation products and increased reduced glutathione concentration.
ISO induced rats also showed massive inflammatory cells infiltration and fibrosis in heart and kidneys.
Furthermore, allopurinol treatment prevented the inflammatory cells infiltration and fibrosis in ISO induced rats.
In conclusion, the results of our study suggest that allopurinol treatment is capable of protecting heart of ISO induced myocardial infarction in rats probably by preventing oxidative stress, inflammation, and fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sagor, Md Abu Taher& Tabassum, Nabila& Potol, Md. Abdullah& Alam, Md. Ashraful. 2015. Xanthine Oxidase Inhibitor, Allopurinol, Prevented Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Aged Rats. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075664
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sagor, Md Abu Taher…[et al.]. Xanthine Oxidase Inhibitor, Allopurinol, Prevented Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Aged Rats. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075664
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sagor, Md Abu Taher& Tabassum, Nabila& Potol, Md. Abdullah& Alam, Md. Ashraful. Xanthine Oxidase Inhibitor, Allopurinol, Prevented Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Aged Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075664
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075664
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر