Xanthine Oxidase Inhibitor, Allopurinol, Prevented Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Aged Rats
Joint Authors
Sagor, Md Abu Taher
Tabassum, Nabila
Potol, Md. Abdullah
Alam, Md. Ashraful
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We evaluated the preventive effect of allopurinol on isoproterenol (ISO) induced myocardial infarction in aged rats.
Twelve- to fourteen-month-old male Long Evans rats were divided into three groups: control, ISO, and ISO + allopurinol.
At the end of the study, all rats were sacrificed for blood and organ sample collection to evaluate biochemical parameters and oxidative stress markers analyses.
Histopathological examinations were also conducted to assess inflammatory cell infiltration and fibrosis in heart and kidneys.
Our investigation revealed that the levels of oxidative stress markers were significantly increased while the level of cellular antioxidants, catalase activity, and glutathione concentration in ISO induced rats decreased.
Treatment with allopurinol to ISO induced rats prevented the elevated activities of AST, ALT, and ALP enzymes, and the levels of lipid peroxidation products and increased reduced glutathione concentration.
ISO induced rats also showed massive inflammatory cells infiltration and fibrosis in heart and kidneys.
Furthermore, allopurinol treatment prevented the inflammatory cells infiltration and fibrosis in ISO induced rats.
In conclusion, the results of our study suggest that allopurinol treatment is capable of protecting heart of ISO induced myocardial infarction in rats probably by preventing oxidative stress, inflammation, and fibrosis.
American Psychological Association (APA)
Sagor, Md Abu Taher& Tabassum, Nabila& Potol, Md. Abdullah& Alam, Md. Ashraful. 2015. Xanthine Oxidase Inhibitor, Allopurinol, Prevented Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Aged Rats. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075664
Modern Language Association (MLA)
Sagor, Md Abu Taher…[et al.]. Xanthine Oxidase Inhibitor, Allopurinol, Prevented Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Aged Rats. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075664
American Medical Association (AMA)
Sagor, Md Abu Taher& Tabassum, Nabila& Potol, Md. Abdullah& Alam, Md. Ashraful. Xanthine Oxidase Inhibitor, Allopurinol, Prevented Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Aged Rats. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075664