A YeastDrosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency
المؤلفون المشاركون
Seguin, Alexandra
Monnier, Véronique
Palandri, Amandine
Bihel, Frédéric
Rera, Michael
Schmitt, Martine
Camadro, Jean-Michel
Tricoire, Hervé
Lesuisse, Emmanuel
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Friedreich’s ataxia (FA) is a rare neurodegenerative disease which is very debilitating for the patients who progressively lose their autonomy.
The lack of efficient therapeutic treatment of the disease strongly argues for urgent need to search for new active compounds that may stop the progression of the disease or prevent the appearance of the symptoms when the genetic defect is diagnosed early enough.
In the present study, we used a yeast strain with a deletion of the frataxin homologue gene as a model of FA cells in a primary screen of two chemical libraries, a fraction of the French National Chemical Library (5500 compounds) and the Prestwick collection (880 compounds).
We ran a secondary screen on Drosophila melanogaster flies expressing reduced levels of frataxin during larval development.
Half of the compounds selected in yeast appeared to be active in flies in this developmental paradigm, and one of the two compounds with highest activities in this assay partially rescued the heart dilatation phenotype resulting from heart specific depletion of frataxin.
The unique complementarity of these two frataxin-deficient models, unicellular and multicellular, appears to be very efficient to select new compounds with improved selectivity, bringing significant perspectives towards improvements in FA therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Seguin, Alexandra& Monnier, Véronique& Palandri, Amandine& Bihel, Frédéric& Rera, Michael& Schmitt, Martine…[et al.]. 2015. A YeastDrosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075692
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Seguin, Alexandra…[et al.]. A YeastDrosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075692
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Seguin, Alexandra& Monnier, Véronique& Palandri, Amandine& Bihel, Frédéric& Rera, Michael& Schmitt, Martine…[et al.]. A YeastDrosophila Screen to Identify New Compounds Overcoming Frataxin Deficiency. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075692
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075692
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر