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Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease
المؤلفون المشاركون
Huang, Ren-Hua
Zhang, Zhi-Hua
Lin, Xin
Wang, Dongtao
Yang, Yajun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-13
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Our evidence demonstrated that CKD upregulated the expression of myostatin, TNF-α, and p-IkBa and downregulated the phosphorylation of PI3K, Akt, and FoxO3a, which were also associated with protein degradation and muscle atrophy.
The autophagosome formation and protein expression of autophagy-related genes were increased in muscle of CKD rats.
The mRNA level and protein expression of MAFbx and MuRF-1 were also upregulated in CKD rats, as well as proteasome activity of 26S.
Moreover, activation of myostatin elicited by TNF-α induces C2C12 myotube atrophy via upregulating the expression of autophagy-related genes, including MAFbx and MuRF1 and proteasome subunits.
Inactivation of FoxO3a triggered by PI3K inhibitor LY294002 prevented the myostatin-induced increase of expression of MuRF1, MAFbx, and LC3-II protein in C2C12 myotubes.
The findings were further consolidated by using siRNA interference and overexpression of myostatin.
Additionally, expression of myostatin was activated by TNF-α via a NF-κB dependent pathway in C2C12 myotubes, while inhibition of NF-κB activity suppressed myostatin and improved myotube atrophy.
Collectively, myostatin mediated CKD-induced muscle catabolism via coordinate activation of the autophagy and the ubiquitin-proteasome systems.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Dongtao& Yang, Yajun& Huang, Ren-Hua& Zhang, Zhi-Hua& Lin, Xin. 2015. Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1075736
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Dongtao…[et al.]. Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1075736
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Dongtao& Yang, Yajun& Huang, Ren-Hua& Zhang, Zhi-Hua& Lin, Xin. Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-18.
https://search.emarefa.net/detail/BIM-1075736
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075736
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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