Melatonin Attenuates Oxidative Damage Induced by Acrylamide In Vitro and In Vivo
المؤلفون المشاركون
Pan, Xiaoqi
Zhu, Lanlan
Lu, Huiping
Wang, Dun
Lu, Qing
Yan, Hong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-21
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Acrylamide (ACR) has been classified as a neurotoxic agent in animals and humans.
Melatonin (MT) has been shown to be potentially effective in preventing oxidative stress related neurodegenerative disorders.
In this study, whether MT exerted a protective effect against ACR-induced oxidative damage was investigated.
Results in cells showed that reactive oxygen species (ROS) and malondialdehyde (MDA) significantly increased after ACR treatment for 24 h.
MT preconditioning or cotreatment with ACR reduced ROS and MDA products, whereas the inhibitory effect of MT on oxidant generation was attenuated by blocking the MT receptor.
Increased DNA fragmentation caused by ACR was significantly decreased by MT coadministration.
In vivo, rats at 40 mg/kg/day ACR by gavage for 12 days showed weight loss and gait abnormality, Purkinje cell nuclear condensation, and DNA damage in rat cerebellum.
MT (i.p) cotreatment with ACR not only recovered weight and gait of rats, but also decreased nuclear condensation and DNA damage in rat cerebellum.
Using MDA generation, glutathione (GSH) level, superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities in rat cerebellum as indicators, MT alleviated ACR-induced lipid peroxidation and depressed antioxidant capacity.
Our results suggest thatMT effectively prevents oxidative damage induced by ACR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pan, Xiaoqi& Zhu, Lanlan& Lu, Huiping& Wang, Dun& Lu, Qing& Yan, Hong. 2015. Melatonin Attenuates Oxidative Damage Induced by Acrylamide In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075739
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pan, Xiaoqi…[et al.]. Melatonin Attenuates Oxidative Damage Induced by Acrylamide In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075739
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pan, Xiaoqi& Zhu, Lanlan& Lu, Huiping& Wang, Dun& Lu, Qing& Yan, Hong. Melatonin Attenuates Oxidative Damage Induced by Acrylamide In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075739
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075739
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر