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Melatonin Attenuates Oxidative Damage Induced by Acrylamide In Vitro and In Vivo
Joint Authors
Pan, Xiaoqi
Zhu, Lanlan
Lu, Huiping
Wang, Dun
Lu, Qing
Yan, Hong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Acrylamide (ACR) has been classified as a neurotoxic agent in animals and humans.
Melatonin (MT) has been shown to be potentially effective in preventing oxidative stress related neurodegenerative disorders.
In this study, whether MT exerted a protective effect against ACR-induced oxidative damage was investigated.
Results in cells showed that reactive oxygen species (ROS) and malondialdehyde (MDA) significantly increased after ACR treatment for 24 h.
MT preconditioning or cotreatment with ACR reduced ROS and MDA products, whereas the inhibitory effect of MT on oxidant generation was attenuated by blocking the MT receptor.
Increased DNA fragmentation caused by ACR was significantly decreased by MT coadministration.
In vivo, rats at 40 mg/kg/day ACR by gavage for 12 days showed weight loss and gait abnormality, Purkinje cell nuclear condensation, and DNA damage in rat cerebellum.
MT (i.p) cotreatment with ACR not only recovered weight and gait of rats, but also decreased nuclear condensation and DNA damage in rat cerebellum.
Using MDA generation, glutathione (GSH) level, superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities in rat cerebellum as indicators, MT alleviated ACR-induced lipid peroxidation and depressed antioxidant capacity.
Our results suggest thatMT effectively prevents oxidative damage induced by ACR.
American Psychological Association (APA)
Pan, Xiaoqi& Zhu, Lanlan& Lu, Huiping& Wang, Dun& Lu, Qing& Yan, Hong. 2015. Melatonin Attenuates Oxidative Damage Induced by Acrylamide In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075739
Modern Language Association (MLA)
Pan, Xiaoqi…[et al.]. Melatonin Attenuates Oxidative Damage Induced by Acrylamide In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1075739
American Medical Association (AMA)
Pan, Xiaoqi& Zhu, Lanlan& Lu, Huiping& Wang, Dun& Lu, Qing& Yan, Hong. Melatonin Attenuates Oxidative Damage Induced by Acrylamide In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1075739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075739