Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice
المؤلفون المشاركون
Jin, Sheng
Pu, Shi-Xin
Hou, Cui-Lan
Ma, Fen-Fen
Li, Na
Li, Xing-Hui
Tan, Bo
Tao, Bei-Bei
Wang, Ming-Jie
Zhu, Yi-Chun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-11
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Aims.
To examine whether hydrogen sulfide (H2S) generation changed in ageing diabetic mouse hearts.
Results.
Compared to mice that were fed tap water only, mice that were fed 30% fructose solution for 15 months exhibited typical characteristics of a severe diabetic phenotype with cardiac hypertrophy, fibrosis, and dysfunction.
H2S levels in plasma, heart tissues, and urine were significantly reduced in these mice as compared to those in controls.
The expression of the H2S-generating enzymes, cystathionine γ-lyase and 3-mercaptopyruvate sulfurtransferase, was significantly decreased in the hearts of fructose-fed mice, whereas cystathionine-β-synthase levels were significantly increased.
Conclusion.
Our results suggest that this ageing diabetic mouse model developed diabetic cardiomyopathy and that H2S levels were reduced in the diabetic heart due to alterations in three H2S-producing enzymes, which may be involved in the pathogenesis of diabetic cardiomyopathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Sheng& Pu, Shi-Xin& Hou, Cui-Lan& Ma, Fen-Fen& Li, Na& Li, Xing-Hui…[et al.]. 2015. Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075761
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Sheng…[et al.]. Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1075761
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Sheng& Pu, Shi-Xin& Hou, Cui-Lan& Ma, Fen-Fen& Li, Na& Li, Xing-Hui…[et al.]. Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075761
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075761
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر