Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice
Joint Authors
Jin, Sheng
Pu, Shi-Xin
Hou, Cui-Lan
Ma, Fen-Fen
Li, Na
Li, Xing-Hui
Tan, Bo
Tao, Bei-Bei
Wang, Ming-Jie
Zhu, Yi-Chun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aims.
To examine whether hydrogen sulfide (H2S) generation changed in ageing diabetic mouse hearts.
Results.
Compared to mice that were fed tap water only, mice that were fed 30% fructose solution for 15 months exhibited typical characteristics of a severe diabetic phenotype with cardiac hypertrophy, fibrosis, and dysfunction.
H2S levels in plasma, heart tissues, and urine were significantly reduced in these mice as compared to those in controls.
The expression of the H2S-generating enzymes, cystathionine γ-lyase and 3-mercaptopyruvate sulfurtransferase, was significantly decreased in the hearts of fructose-fed mice, whereas cystathionine-β-synthase levels were significantly increased.
Conclusion.
Our results suggest that this ageing diabetic mouse model developed diabetic cardiomyopathy and that H2S levels were reduced in the diabetic heart due to alterations in three H2S-producing enzymes, which may be involved in the pathogenesis of diabetic cardiomyopathy.
American Psychological Association (APA)
Jin, Sheng& Pu, Shi-Xin& Hou, Cui-Lan& Ma, Fen-Fen& Li, Na& Li, Xing-Hui…[et al.]. 2015. Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075761
Modern Language Association (MLA)
Jin, Sheng…[et al.]. Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1075761
American Medical Association (AMA)
Jin, Sheng& Pu, Shi-Xin& Hou, Cui-Lan& Ma, Fen-Fen& Li, Na& Li, Xing-Hui…[et al.]. Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1075761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075761