Role of Circulating miRNAs as Biomarkers in Idiopathic Pulmonary Arterial Hypertension: Possible Relevance of miR-23a
المؤلفون المشاركون
Ramon, Mercedes
Furest, Idelfonso
Carda, Carmen
Cortijo Gimeno, Julio
Sarrion, Irene
Juan, Gustavo
Mata, Manuel
Milian, Lara
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Idiopathic pulmonary hypertension (IPAH) is a rare disease characterized by a progressive increase in pulmonary vascular resistance leading to heart failure.
MicroRNAs (miRNAs) are small noncoding RNAs that control the expression of genes, including some involved in the progression of IPAH, as studied in animals and lung tissue.
These molecules circulate freely in the blood and their expression is associated with the progression of different vascular pathologies.
Here, we studied the expression profile of circulating miRNAs in 12 well-characterized IPAH patients using microarrays.
We found significant changes in 61 miRNAs, of which the expression of miR23a was correlated with the patients’ pulmonary function.
We also studied the expression profile of circulating messenger RNA (mRNAs) and found that miR23a controlled 17% of the significantly changed mRNA, including PGC1α, which was recently associated with the progression of IPAH.
Finally we found that silencing of miR23a resulted in an increase of the expression of PGC1α, as well as in its well-known regulated genes CYC, SOD, NRF2, and HO1.
The results point to the utility of circulating miRNA expression as a biomarker of disease progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sarrion, Irene& Milian, Lara& Juan, Gustavo& Ramon, Mercedes& Furest, Idelfonso& Carda, Carmen…[et al.]. 2015. Role of Circulating miRNAs as Biomarkers in Idiopathic Pulmonary Arterial Hypertension: Possible Relevance of miR-23a. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075775
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sarrion, Irene…[et al.]. Role of Circulating miRNAs as Biomarkers in Idiopathic Pulmonary Arterial Hypertension: Possible Relevance of miR-23a. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075775
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sarrion, Irene& Milian, Lara& Juan, Gustavo& Ramon, Mercedes& Furest, Idelfonso& Carda, Carmen…[et al.]. Role of Circulating miRNAs as Biomarkers in Idiopathic Pulmonary Arterial Hypertension: Possible Relevance of miR-23a. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075775
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075775
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر