Role of Circulating miRNAs as Biomarkers in Idiopathic Pulmonary Arterial Hypertension: Possible Relevance of miR-23a
Joint Authors
Ramon, Mercedes
Furest, Idelfonso
Carda, Carmen
Cortijo Gimeno, Julio
Sarrion, Irene
Juan, Gustavo
Mata, Manuel
Milian, Lara
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Idiopathic pulmonary hypertension (IPAH) is a rare disease characterized by a progressive increase in pulmonary vascular resistance leading to heart failure.
MicroRNAs (miRNAs) are small noncoding RNAs that control the expression of genes, including some involved in the progression of IPAH, as studied in animals and lung tissue.
These molecules circulate freely in the blood and their expression is associated with the progression of different vascular pathologies.
Here, we studied the expression profile of circulating miRNAs in 12 well-characterized IPAH patients using microarrays.
We found significant changes in 61 miRNAs, of which the expression of miR23a was correlated with the patients’ pulmonary function.
We also studied the expression profile of circulating messenger RNA (mRNAs) and found that miR23a controlled 17% of the significantly changed mRNA, including PGC1α, which was recently associated with the progression of IPAH.
Finally we found that silencing of miR23a resulted in an increase of the expression of PGC1α, as well as in its well-known regulated genes CYC, SOD, NRF2, and HO1.
The results point to the utility of circulating miRNA expression as a biomarker of disease progression.
American Psychological Association (APA)
Sarrion, Irene& Milian, Lara& Juan, Gustavo& Ramon, Mercedes& Furest, Idelfonso& Carda, Carmen…[et al.]. 2015. Role of Circulating miRNAs as Biomarkers in Idiopathic Pulmonary Arterial Hypertension: Possible Relevance of miR-23a. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075775
Modern Language Association (MLA)
Sarrion, Irene…[et al.]. Role of Circulating miRNAs as Biomarkers in Idiopathic Pulmonary Arterial Hypertension: Possible Relevance of miR-23a. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075775
American Medical Association (AMA)
Sarrion, Irene& Milian, Lara& Juan, Gustavo& Ramon, Mercedes& Furest, Idelfonso& Carda, Carmen…[et al.]. Role of Circulating miRNAs as Biomarkers in Idiopathic Pulmonary Arterial Hypertension: Possible Relevance of miR-23a. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075775