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Rimonabant Improves OxidativeNitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease
المؤلفون المشاركون
Jorgačević, Bojan
Mladenović, Dušan
Ninković, Milica
Vesković, Milena
Dragutinović, Vesna
Vatazević, Aleksandar
Vučević, Danijela
Ješić Vukićević, Rada
Radosavljević, Tatjana
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The present study deals with the effects of rimonabant on oxidative/nitrosative stress in high diet- (HFD-) induced experimental nonalcoholic fatty liver disease (NAFLD).
Male mice C57BL/6 were divided into the following groups: control group fed with control diet for 20 weeks (C; n=6); group fed with HFD for 20 weeks (HF; n=6); group fed with standard diet and treated with rimonabant after 18 weeks (R; n=9); group fed with HFD and treated with rimonabant after 18 weeks (HFR; n=10).
Daily dose of rimonabant (10 mg/kg) was administered to HFR and R group by oral gavage for two weeks.
Treatment induced a decrease in hepatic malondialdehyde concentration in HFR group compared to HF group (P<0.01).
The concentration of nitrites + nitrates in liver was decreased in HFR group compared to HF group (P<0.01).
Liver content of reduced glutathione was higher in HFR group compared to HF group (P<0.01).
Total liver superoxide dismutase activity in HFR group was decreased in comparison with HF group (P<0.01).
It was found that rimonabant may influence hepatic iron, zinc, copper, and manganese status.
Our study indicates potential usefulness of cannabinoid receptor type 1 blockade in the treatment of HFD-induced NAFLD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jorgačević, Bojan& Mladenović, Dušan& Ninković, Milica& Vesković, Milena& Dragutinović, Vesna& Vatazević, Aleksandar…[et al.]. 2015. Rimonabant Improves OxidativeNitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075792
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jorgačević, Bojan…[et al.]. Rimonabant Improves OxidativeNitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075792
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jorgačević, Bojan& Mladenović, Dušan& Ninković, Milica& Vesković, Milena& Dragutinović, Vesna& Vatazević, Aleksandar…[et al.]. Rimonabant Improves OxidativeNitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075792
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075792
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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