Rimonabant Improves OxidativeNitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease
Joint Authors
Jorgačević, Bojan
Mladenović, Dušan
Ninković, Milica
Vesković, Milena
Dragutinović, Vesna
Vatazević, Aleksandar
Vučević, Danijela
Ješić Vukićević, Rada
Radosavljević, Tatjana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The present study deals with the effects of rimonabant on oxidative/nitrosative stress in high diet- (HFD-) induced experimental nonalcoholic fatty liver disease (NAFLD).
Male mice C57BL/6 were divided into the following groups: control group fed with control diet for 20 weeks (C; n=6); group fed with HFD for 20 weeks (HF; n=6); group fed with standard diet and treated with rimonabant after 18 weeks (R; n=9); group fed with HFD and treated with rimonabant after 18 weeks (HFR; n=10).
Daily dose of rimonabant (10 mg/kg) was administered to HFR and R group by oral gavage for two weeks.
Treatment induced a decrease in hepatic malondialdehyde concentration in HFR group compared to HF group (P<0.01).
The concentration of nitrites + nitrates in liver was decreased in HFR group compared to HF group (P<0.01).
Liver content of reduced glutathione was higher in HFR group compared to HF group (P<0.01).
Total liver superoxide dismutase activity in HFR group was decreased in comparison with HF group (P<0.01).
It was found that rimonabant may influence hepatic iron, zinc, copper, and manganese status.
Our study indicates potential usefulness of cannabinoid receptor type 1 blockade in the treatment of HFD-induced NAFLD.
American Psychological Association (APA)
Jorgačević, Bojan& Mladenović, Dušan& Ninković, Milica& Vesković, Milena& Dragutinović, Vesna& Vatazević, Aleksandar…[et al.]. 2015. Rimonabant Improves OxidativeNitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075792
Modern Language Association (MLA)
Jorgačević, Bojan…[et al.]. Rimonabant Improves OxidativeNitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075792
American Medical Association (AMA)
Jorgačević, Bojan& Mladenović, Dušan& Ninković, Milica& Vesković, Milena& Dragutinović, Vesna& Vatazević, Aleksandar…[et al.]. Rimonabant Improves OxidativeNitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075792