![](/images/graphics-bg.png)
Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice
المؤلفون المشاركون
Choi, Yung Hyun
Han, Min Ho
Kim, Joo Wan
Kim, Cheol Min
Kim, Ki Young
Kim, Sung Goo
Kim, Gi-Young
Hwang, Hye Jin
Kim, Byung Woo
Ku, Sae-Kwang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-12
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
The objective of this study was to assess the possible beneficial skeletal muscle preserving effects of ethanol extract of Schisandrae Fructus (EESF) on sciatic neurectomy- (NTX-) induced hindlimb muscle atrophy in mice.
Here, calf muscle atrophy was induced by unilateral right sciatic NTX.
In order to investigate whether administration of EESF prevents or improves sciatic NTX-induced muscle atrophy, EESF was administered orally.
Our results indicated that EESF dose-dependently diminished the decreases in markers of muscle mass and activity levels, and the increases in markers of muscle damage and fibrosis, inflammatory cell infiltration, cytokines, and apoptotic events in the gastrocnemius muscle bundles are induced by NTX.
Additionally, destruction of gastrocnemius antioxidant defense systems after NTX was dose-dependently protected by treatment with EESF.
EESF also upregulated muscle-specific mRNAs involved in muscle protein synthesis but downregulated those involved in protein degradation.
The overall effects of 500 mg/kg EESF were similar to those of 50 mg/kg oxymetholone, but it showed more favorable antioxidant effects.
The present results suggested that EESF exerts a favorable ameliorating effect on muscle atrophy induced by NTX, through anti-inflammatory and antioxidant effects related to muscle fiber protective effects and via an increase in protein synthesis and a decrease in protein degradation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Joo Wan& Ku, Sae-Kwang& Kim, Ki Young& Kim, Sung Goo& Han, Min Ho& Kim, Gi-Young…[et al.]. 2015. Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1075800
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Joo Wan…[et al.]. Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1075800
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Joo Wan& Ku, Sae-Kwang& Kim, Ki Young& Kim, Sung Goo& Han, Min Ho& Kim, Gi-Young…[et al.]. Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1075800
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075800
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)