Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice
Joint Authors
Choi, Yung Hyun
Han, Min Ho
Kim, Joo Wan
Kim, Cheol Min
Kim, Ki Young
Kim, Sung Goo
Kim, Gi-Young
Hwang, Hye Jin
Kim, Byung Woo
Ku, Sae-Kwang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-12
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The objective of this study was to assess the possible beneficial skeletal muscle preserving effects of ethanol extract of Schisandrae Fructus (EESF) on sciatic neurectomy- (NTX-) induced hindlimb muscle atrophy in mice.
Here, calf muscle atrophy was induced by unilateral right sciatic NTX.
In order to investigate whether administration of EESF prevents or improves sciatic NTX-induced muscle atrophy, EESF was administered orally.
Our results indicated that EESF dose-dependently diminished the decreases in markers of muscle mass and activity levels, and the increases in markers of muscle damage and fibrosis, inflammatory cell infiltration, cytokines, and apoptotic events in the gastrocnemius muscle bundles are induced by NTX.
Additionally, destruction of gastrocnemius antioxidant defense systems after NTX was dose-dependently protected by treatment with EESF.
EESF also upregulated muscle-specific mRNAs involved in muscle protein synthesis but downregulated those involved in protein degradation.
The overall effects of 500 mg/kg EESF were similar to those of 50 mg/kg oxymetholone, but it showed more favorable antioxidant effects.
The present results suggested that EESF exerts a favorable ameliorating effect on muscle atrophy induced by NTX, through anti-inflammatory and antioxidant effects related to muscle fiber protective effects and via an increase in protein synthesis and a decrease in protein degradation.
American Psychological Association (APA)
Kim, Joo Wan& Ku, Sae-Kwang& Kim, Ki Young& Kim, Sung Goo& Han, Min Ho& Kim, Gi-Young…[et al.]. 2015. Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1075800
Modern Language Association (MLA)
Kim, Joo Wan…[et al.]. Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1075800
American Medical Association (AMA)
Kim, Joo Wan& Ku, Sae-Kwang& Kim, Ki Young& Kim, Sung Goo& Han, Min Ho& Kim, Gi-Young…[et al.]. Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1075800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075800