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Cardioprotective Effects of Voluntary Exercise in a Rat Model: Role of Matrix Metalloproteinase-2
المؤلفون المشاركون
Varga, Csaba
Gyöngyösi, Mariann
Szalai, Zita
Baráth, Zoltán
Csonka, Anett
Veszelka, Médea
Radák, Zsolt
Ménesi, Rudolf
Kupai, Krisztina
Berkó, Anikó
Pósa, Anikó
Szabó, Renáta
Pávó, Imre
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Regular exercise at moderate intensity reduces cardiovascular risks.
Matrix metalloproteinases (MMPs) play a major role in cardiac remodeling, facilitating physiological adaptation to exercise.
The aim of this study was to examine the influence of voluntary physical exercise on the MMP-2 enzyme activity and to investigate the cardiac performance by measurement of angina susceptibility of the heart, the basal blood pressure, the surviving aorta ring contraction, and the cardiac infarct size after I/R-induced injury.
Methods.
Male Wistar rats were divided into control and exercising groups.
After a 6-week period, the serum level of MMP-2, basal blood pressure, cardiac angina susceptibility (the ST segment depression provoked by epinephrine and 30 s later phentolamine), AVP-induced heart perfusion and aorta ring contraction, infarct size following 30 min ischemia and 120 min reperfusion, and coronary effluent MMP-2 activity were measured.
Results.
Voluntary wheel-running exercise decreased both the sera (64 kDa and 72 kDa) and the coronary effluent (64 kDa) MMP-2 level, reduced the development of ST depression, improved the isolated heart perfusion, and decreased the ratio of infarct size.
Conclusion.
6 weeks of voluntary exercise training preserved the heart against cardiac injury.
This protective mechanism might be associated with the decreased activity of MMP-2.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pósa, Anikó& Szabó, Renáta& Kupai, Krisztina& Baráth, Zoltán& Szalai, Zita& Csonka, Anett…[et al.]. 2015. Cardioprotective Effects of Voluntary Exercise in a Rat Model: Role of Matrix Metalloproteinase-2. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075802
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pósa, Anikó…[et al.]. Cardioprotective Effects of Voluntary Exercise in a Rat Model: Role of Matrix Metalloproteinase-2. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075802
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pósa, Anikó& Szabó, Renáta& Kupai, Krisztina& Baráth, Zoltán& Szalai, Zita& Csonka, Anett…[et al.]. Cardioprotective Effects of Voluntary Exercise in a Rat Model: Role of Matrix Metalloproteinase-2. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075802
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075802
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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