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Cardioprotective Effects of Voluntary Exercise in a Rat Model: Role of Matrix Metalloproteinase-2
Joint Authors
Varga, Csaba
Gyöngyösi, Mariann
Szalai, Zita
Baráth, Zoltán
Csonka, Anett
Veszelka, Médea
Radák, Zsolt
Ménesi, Rudolf
Kupai, Krisztina
Berkó, Anikó
Pósa, Anikó
Szabó, Renáta
Pávó, Imre
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Regular exercise at moderate intensity reduces cardiovascular risks.
Matrix metalloproteinases (MMPs) play a major role in cardiac remodeling, facilitating physiological adaptation to exercise.
The aim of this study was to examine the influence of voluntary physical exercise on the MMP-2 enzyme activity and to investigate the cardiac performance by measurement of angina susceptibility of the heart, the basal blood pressure, the surviving aorta ring contraction, and the cardiac infarct size after I/R-induced injury.
Methods.
Male Wistar rats were divided into control and exercising groups.
After a 6-week period, the serum level of MMP-2, basal blood pressure, cardiac angina susceptibility (the ST segment depression provoked by epinephrine and 30 s later phentolamine), AVP-induced heart perfusion and aorta ring contraction, infarct size following 30 min ischemia and 120 min reperfusion, and coronary effluent MMP-2 activity were measured.
Results.
Voluntary wheel-running exercise decreased both the sera (64 kDa and 72 kDa) and the coronary effluent (64 kDa) MMP-2 level, reduced the development of ST depression, improved the isolated heart perfusion, and decreased the ratio of infarct size.
Conclusion.
6 weeks of voluntary exercise training preserved the heart against cardiac injury.
This protective mechanism might be associated with the decreased activity of MMP-2.
American Psychological Association (APA)
Pósa, Anikó& Szabó, Renáta& Kupai, Krisztina& Baráth, Zoltán& Szalai, Zita& Csonka, Anett…[et al.]. 2015. Cardioprotective Effects of Voluntary Exercise in a Rat Model: Role of Matrix Metalloproteinase-2. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075802
Modern Language Association (MLA)
Pósa, Anikó…[et al.]. Cardioprotective Effects of Voluntary Exercise in a Rat Model: Role of Matrix Metalloproteinase-2. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1075802
American Medical Association (AMA)
Pósa, Anikó& Szabó, Renáta& Kupai, Krisztina& Baráth, Zoltán& Szalai, Zita& Csonka, Anett…[et al.]. Cardioprotective Effects of Voluntary Exercise in a Rat Model: Role of Matrix Metalloproteinase-2. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1075802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075802