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Increased Susceptibility of Gracilinanus microtarsus Liver Mitochondria to Ca+2-Induced Permeability Transition Is Associated with a More Oxidized State of NAD(P)
المؤلفون المشاركون
Ronchi, Juliana A.
Henning, Barbara
Ravagnani, Felipe G.
Figueira, Tiago R.
Castilho, Roger F.
dos Reis, Sergio F.
Vercesi, Anibal E.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In addition to be the cell’s powerhouse, mitochondria also contain a cell death machinery that includes highly regulated processes such as the membrane permeability transition pore (PTP) and reactive oxygen species (ROS) production.
In this context, the results presented here provide evidence that liver mitochondria isolated from Gracilinanus microtarsus, a small and short life span (one year) marsupial, when compared to mice, are much more susceptible to PTP opening in association with a poor NADPH dependent antioxidant capacity.
Liver mitochondria isolated from the marsupial are well coupled and take up Ca 2+ but exhibited a much lower Ca 2+ retention capacity than mouse mitochondria.
Although the known PTP inhibitors cyclosporin A, ADP, and ATP significantly increased the marsupial mitochondria capacity to retain Ca 2+ , their effects were much larger in mice than in marsupial mitochondria.
Both fluorescence and HPLC analysis of mitochondrial nicotinamide nucleotides showed that both content and state of reduction (mainly of NADPH) were lower in the marsupial mitochondria than in mice mitochondria despite the similarity in the activity of the glutathione peroxidase/reductase system.
Overall, these data suggest that PTP opening is an important event in processes of Ca 2+ signalling to cell death mediated by mitochondrial redox imbalance in G.
microtarsus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ronchi, Juliana A.& Henning, Barbara& Ravagnani, Felipe G.& Figueira, Tiago R.& Castilho, Roger F.& dos Reis, Sergio F.…[et al.]. 2015. Increased Susceptibility of Gracilinanus microtarsus Liver Mitochondria to Ca+2-Induced Permeability Transition Is Associated with a More Oxidized State of NAD(P). Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075818
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ronchi, Juliana A.…[et al.]. Increased Susceptibility of Gracilinanus microtarsus Liver Mitochondria to Ca+2-Induced Permeability Transition Is Associated with a More Oxidized State of NAD(P). Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075818
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ronchi, Juliana A.& Henning, Barbara& Ravagnani, Felipe G.& Figueira, Tiago R.& Castilho, Roger F.& dos Reis, Sergio F.…[et al.]. Increased Susceptibility of Gracilinanus microtarsus Liver Mitochondria to Ca+2-Induced Permeability Transition Is Associated with a More Oxidized State of NAD(P). Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075818
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075818
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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