Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease
المؤلفون المشاركون
Brito, Gerly Anne de Castro
Neves, Kelly Rose
Nobre, Hélio Vitoriano
de Andrade, Geanne Matos
Viana, Glauce Socorro de Barros
Leal, Luzia Kalyne Almeida Moreira
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-29
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Pentoxifylline (PTX) is a phosphodiesterase inhibitor with anti-TNF-alpha activity, associated with its anti-inflammatory action.
Considering Parkinson’s disease (PD) as a neuroinflammatory disorder, the objectives were to evaluate PTX neuroprotective properties, in a model of PD.
Male Wistar rats, divided into sham-operated (SO), untreated 6-OHDA, and 6-OHDA treated with PTX (10, 25, and 50 mg/kg) groups, received a unilateral 6-OHDA injection, except the SO group administered with saline.
Treatments started 24 h after surgery and continued for 15 days when the animals were submitted to apomorphine-induced rotations, open field, and forced swimming tests.
At the next day, they were euthanized and their striata processed for neurochemical (DA and DOPAC determinations), histological, and immunohistochemical (Fluoro-Jade, TH, DAT, OX-42, TNF-alpha, COX-2, and iNOS) studies.
PTX reversed the behavioral changes observed in the untreated 6-OHDA animals.
Furthermore, PTX partially reversed the decrease in DA contents and improved neuronal viability.
In addition, decreases in immunostaining for TH and dopamine transporter (DAT) were reversed.
The untreated 6-OHDA group showed intense OX-42, TNF-alpha, COX-2, and iNOS immunoreactivities, which were attenuated by PTX.
In conclusion, we demonstrated a neuroprotective effect of PTX, possibly related to its anti-inflammatory and antioxidant actions, indicating its potential as an adjunct treatment for PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Neves, Kelly Rose& Nobre, Hélio Vitoriano& Leal, Luzia Kalyne Almeida Moreira& de Andrade, Geanne Matos& Brito, Gerly Anne de Castro& Viana, Glauce Socorro de Barros. 2015. Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075845
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Neves, Kelly Rose…[et al.]. Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease. Parkinson’s Disease No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1075845
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Neves, Kelly Rose& Nobre, Hélio Vitoriano& Leal, Luzia Kalyne Almeida Moreira& de Andrade, Geanne Matos& Brito, Gerly Anne de Castro& Viana, Glauce Socorro de Barros. Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075845
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075845
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر