Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease
Joint Authors
Brito, Gerly Anne de Castro
Neves, Kelly Rose
Nobre, Hélio Vitoriano
de Andrade, Geanne Matos
Viana, Glauce Socorro de Barros
Leal, Luzia Kalyne Almeida Moreira
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Pentoxifylline (PTX) is a phosphodiesterase inhibitor with anti-TNF-alpha activity, associated with its anti-inflammatory action.
Considering Parkinson’s disease (PD) as a neuroinflammatory disorder, the objectives were to evaluate PTX neuroprotective properties, in a model of PD.
Male Wistar rats, divided into sham-operated (SO), untreated 6-OHDA, and 6-OHDA treated with PTX (10, 25, and 50 mg/kg) groups, received a unilateral 6-OHDA injection, except the SO group administered with saline.
Treatments started 24 h after surgery and continued for 15 days when the animals were submitted to apomorphine-induced rotations, open field, and forced swimming tests.
At the next day, they were euthanized and their striata processed for neurochemical (DA and DOPAC determinations), histological, and immunohistochemical (Fluoro-Jade, TH, DAT, OX-42, TNF-alpha, COX-2, and iNOS) studies.
PTX reversed the behavioral changes observed in the untreated 6-OHDA animals.
Furthermore, PTX partially reversed the decrease in DA contents and improved neuronal viability.
In addition, decreases in immunostaining for TH and dopamine transporter (DAT) were reversed.
The untreated 6-OHDA group showed intense OX-42, TNF-alpha, COX-2, and iNOS immunoreactivities, which were attenuated by PTX.
In conclusion, we demonstrated a neuroprotective effect of PTX, possibly related to its anti-inflammatory and antioxidant actions, indicating its potential as an adjunct treatment for PD.
American Psychological Association (APA)
Neves, Kelly Rose& Nobre, Hélio Vitoriano& Leal, Luzia Kalyne Almeida Moreira& de Andrade, Geanne Matos& Brito, Gerly Anne de Castro& Viana, Glauce Socorro de Barros. 2015. Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075845
Modern Language Association (MLA)
Neves, Kelly Rose…[et al.]. Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease. Parkinson’s Disease No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1075845
American Medical Association (AMA)
Neves, Kelly Rose& Nobre, Hélio Vitoriano& Leal, Luzia Kalyne Almeida Moreira& de Andrade, Geanne Matos& Brito, Gerly Anne de Castro& Viana, Glauce Socorro de Barros. Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in the 6-OHDA Model of Parkinson’s Disease. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1075845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075845