Effects of Night-Time Use of Rotigotine on Nocturnal Symptoms in Parkinson’s Disease

الملخص EN

Objectives.

This open-label study assessed the efficacy and safety of exclusive night-time administration of transdermal rotigotine in patients with nocturnal and early morning PD symptoms.

Methods.

Patients with PD and nocturnal and early morning symptoms received transdermal rotigotine patches (2–16 mg/24 h) applied in the evening and removed in the morning for 3 months.

Sleep disturbance was assessed with modified Parkinson’s Disease Sleep Scale (PDSS-2).

Other outcomes included a pain visual analogue scale (VAS) and short-form Parkinson’s Disease Questionnaire (PDQ-8) for quality of life.

Results.

74 patients completed treatment in this study.

At the end of treatment, PDSS-2 total score had improved by mean 10.9 points from baseline (p < 0.001).

All three PDSS-2 domain scores (sleep disturbances, nocturnal motor symptoms, and nocturnal symptoms) were also significantly improved by 41%, 56%, and 48%, respectively (p < 0.001).

VAS-pain score decreased from 3.2 to 2.3 (p < 0.001).

PDQ-8 score decreased from 23.8 to 18.1 (p < 0.001).

The most frequently reported adverse events included nausea (9%), anxiety (4%), and dizziness (4%).

Conclusions.

Night-time administration of transdermal rotigotine is an effective and well tolerated treatment for nocturnal symptoms in patients with PD.