Effects of Night-Time Use of Rotigotine on Nocturnal Symptoms in Parkinson’s Disease
Joint Authors
Delgado, Tania
Vallderiola, Francesc
Compta, Yaroslau
Aparicio, Javier
Tarradellas, Jaume
Salazar, Gabriel
Oliver, Josep María
Callén, Antonio
Nobbe, Fritz
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
This open-label study assessed the efficacy and safety of exclusive night-time administration of transdermal rotigotine in patients with nocturnal and early morning PD symptoms.
Methods.
Patients with PD and nocturnal and early morning symptoms received transdermal rotigotine patches (2–16 mg/24 h) applied in the evening and removed in the morning for 3 months.
Sleep disturbance was assessed with modified Parkinson’s Disease Sleep Scale (PDSS-2).
Other outcomes included a pain visual analogue scale (VAS) and short-form Parkinson’s Disease Questionnaire (PDQ-8) for quality of life.
Results.
74 patients completed treatment in this study.
At the end of treatment, PDSS-2 total score had improved by mean 10.9 points from baseline (p < 0.001).
All three PDSS-2 domain scores (sleep disturbances, nocturnal motor symptoms, and nocturnal symptoms) were also significantly improved by 41%, 56%, and 48%, respectively (p < 0.001).
VAS-pain score decreased from 3.2 to 2.3 (p < 0.001).
PDQ-8 score decreased from 23.8 to 18.1 (p < 0.001).
The most frequently reported adverse events included nausea (9%), anxiety (4%), and dizziness (4%).
Conclusions.
Night-time administration of transdermal rotigotine is an effective and well tolerated treatment for nocturnal symptoms in patients with PD.
American Psychological Association (APA)
Vallderiola, Francesc& Compta, Yaroslau& Aparicio, Javier& Tarradellas, Jaume& Salazar, Gabriel& Oliver, Josep María…[et al.]. 2015. Effects of Night-Time Use of Rotigotine on Nocturnal Symptoms in Parkinson’s Disease. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075883
Modern Language Association (MLA)
Vallderiola, Francesc…[et al.]. Effects of Night-Time Use of Rotigotine on Nocturnal Symptoms in Parkinson’s Disease. Parkinson’s Disease No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1075883
American Medical Association (AMA)
Vallderiola, Francesc& Compta, Yaroslau& Aparicio, Javier& Tarradellas, Jaume& Salazar, Gabriel& Oliver, Josep María…[et al.]. Effects of Night-Time Use of Rotigotine on Nocturnal Symptoms in Parkinson’s Disease. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1075883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075883