Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease
المؤلفون المشاركون
Su, Jingjing
Li, Xiang-Yun
Mei, Guang-Hai
Dong, Qiang
Zhang, Yu
Guo, Zhuang-Li
Tang, Yu-Ping
Jin, Xue-Hong
Zhou, Hou-Guang
Huang, Yan-Yan
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Aim.
In this study we examined the influence of tetrandrine (Tet) on the neuroprotective effects of glutathione (GSH) in the 6-hydroxydopamine- (6-OHDA-) lesioned rat model of Parkinson’s disease (PD).
Methods.
Levels in the redox system, dopamine (DA) metabolism, dopaminergic neuronal survival, and apoptosis of the substantia nigra (SN) and striatum, as well as the rotational behavior of animals were examined after a 50-day administration of GSH + Tet (or GSH) and/or L-3,4-dihydroxyphenylalanine (L-dopa) to PD rats.
Ethics Committee of Huashan Hospital, Fudan University approved the protocol (number SYXK2009-0082).
Results.
Administration of GSH or Tet alone did not show any significant effects on the factors evaluated in the PD rats.
However, in the GSH + Tet group, we observed markedly decreased oxidative damage, inhibition of DA metabolism and enhanced DA synthesis, increased tyrosine hydroxylase- (TH-) immunopositive neuronal survival, and delayed apoptosis of dopaminergic neurons in the SN.
Animal rotational behavior was improved in the GSH + Tet group.
Additionally, coadministration of GSH + Tet appeared to offset the possible oxidative neurotoxicity induced by L-dopa.
Conclusion.
In this study, we demonstrated that tetrandrine allowed occurrence of the neuroprotective effect of glutathione probably due to inhibition of P-glycoprotein on 6-hydroxydopamine-lesioned rat models of Parkinson’s disease, including rats undergoing long-term L-dopa treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xiang-Yun& Mei, Guang-Hai& Dong, Qiang& Zhang, Yu& Guo, Zhuang-Li& Su, Jingjing…[et al.]. 2015. Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075925
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xiang-Yun…[et al.]. Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease. Parkinson’s Disease No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075925
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xiang-Yun& Mei, Guang-Hai& Dong, Qiang& Zhang, Yu& Guo, Zhuang-Li& Su, Jingjing…[et al.]. Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075925
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075925
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر