Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease
Joint Authors
Su, Jingjing
Li, Xiang-Yun
Mei, Guang-Hai
Dong, Qiang
Zhang, Yu
Guo, Zhuang-Li
Tang, Yu-Ping
Jin, Xue-Hong
Zhou, Hou-Guang
Huang, Yan-Yan
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aim.
In this study we examined the influence of tetrandrine (Tet) on the neuroprotective effects of glutathione (GSH) in the 6-hydroxydopamine- (6-OHDA-) lesioned rat model of Parkinson’s disease (PD).
Methods.
Levels in the redox system, dopamine (DA) metabolism, dopaminergic neuronal survival, and apoptosis of the substantia nigra (SN) and striatum, as well as the rotational behavior of animals were examined after a 50-day administration of GSH + Tet (or GSH) and/or L-3,4-dihydroxyphenylalanine (L-dopa) to PD rats.
Ethics Committee of Huashan Hospital, Fudan University approved the protocol (number SYXK2009-0082).
Results.
Administration of GSH or Tet alone did not show any significant effects on the factors evaluated in the PD rats.
However, in the GSH + Tet group, we observed markedly decreased oxidative damage, inhibition of DA metabolism and enhanced DA synthesis, increased tyrosine hydroxylase- (TH-) immunopositive neuronal survival, and delayed apoptosis of dopaminergic neurons in the SN.
Animal rotational behavior was improved in the GSH + Tet group.
Additionally, coadministration of GSH + Tet appeared to offset the possible oxidative neurotoxicity induced by L-dopa.
Conclusion.
In this study, we demonstrated that tetrandrine allowed occurrence of the neuroprotective effect of glutathione probably due to inhibition of P-glycoprotein on 6-hydroxydopamine-lesioned rat models of Parkinson’s disease, including rats undergoing long-term L-dopa treatment.
American Psychological Association (APA)
Li, Xiang-Yun& Mei, Guang-Hai& Dong, Qiang& Zhang, Yu& Guo, Zhuang-Li& Su, Jingjing…[et al.]. 2015. Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075925
Modern Language Association (MLA)
Li, Xiang-Yun…[et al.]. Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease. Parkinson’s Disease No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075925
American Medical Association (AMA)
Li, Xiang-Yun& Mei, Guang-Hai& Dong, Qiang& Zhang, Yu& Guo, Zhuang-Li& Su, Jingjing…[et al.]. Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1075925