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Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009
المؤلفون المشاركون
Bruland, Øyvind S.
Berner, Kjetil
Johannesen, Tom Børge
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
To describe epidemiological, clinical characteristics and treatment outcomes of low-grade osteosarcoma (LGOS), including dedifferentiated osteosarcoma (DLGOS).
Method.
We analysed a nationwide cohort comprised of patients with histologically verified LGOS and DLGOS between 1975 and 2009, based on registry sources supplemented with clinical records from hospitals involved in sarcoma management.
Results.
Fifty-four patients were identified, 12 of whom had DLGOS.
The annual incidence for all patients was 0.3 per million, with the peak incidence in the third decade of the life.
Fifteen patients experienced local relapses during follow-up and ten developed metastatic diseases, including three at primary diagnosis.
Patients with DLGOS dominated the metastatic relapse group.
The five-year sarcoma-specific survival rate was 91%, with no documented improvement over time.
Free margin following surgical resection of the primary tumour had a positive impact on survival.
As expected, both local relapse and metastasis during follow-up were associated with an unfavourable outcome.
Radiotherapy predicted poor survival due to the selection of high-risk patients in need of such treatment.
Neither higher age nor axial tumour localisation was adverse prognostic factors.
Conclusion.
LGOS has an excellent prognosis when surgically resected with a free margin; however, LGOS has the potential to dedifferentiate and metastasize with a poor outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Berner, Kjetil& Johannesen, Tom Børge& Bruland, Øyvind S.. 2015. Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009. Complexity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076109
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Berner, Kjetil…[et al.]. Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009. Complexity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1076109
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Berner, Kjetil& Johannesen, Tom Børge& Bruland, Øyvind S.. Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009. Complexity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076109
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076109
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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