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Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009
Joint Authors
Bruland, Øyvind S.
Berner, Kjetil
Johannesen, Tom Børge
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-08-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To describe epidemiological, clinical characteristics and treatment outcomes of low-grade osteosarcoma (LGOS), including dedifferentiated osteosarcoma (DLGOS).
Method.
We analysed a nationwide cohort comprised of patients with histologically verified LGOS and DLGOS between 1975 and 2009, based on registry sources supplemented with clinical records from hospitals involved in sarcoma management.
Results.
Fifty-four patients were identified, 12 of whom had DLGOS.
The annual incidence for all patients was 0.3 per million, with the peak incidence in the third decade of the life.
Fifteen patients experienced local relapses during follow-up and ten developed metastatic diseases, including three at primary diagnosis.
Patients with DLGOS dominated the metastatic relapse group.
The five-year sarcoma-specific survival rate was 91%, with no documented improvement over time.
Free margin following surgical resection of the primary tumour had a positive impact on survival.
As expected, both local relapse and metastasis during follow-up were associated with an unfavourable outcome.
Radiotherapy predicted poor survival due to the selection of high-risk patients in need of such treatment.
Neither higher age nor axial tumour localisation was adverse prognostic factors.
Conclusion.
LGOS has an excellent prognosis when surgically resected with a free margin; however, LGOS has the potential to dedifferentiate and metastasize with a poor outcome.
American Psychological Association (APA)
Berner, Kjetil& Johannesen, Tom Børge& Bruland, Øyvind S.. 2015. Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009. Complexity،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076109
Modern Language Association (MLA)
Berner, Kjetil…[et al.]. Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009. Complexity No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1076109
American Medical Association (AMA)
Berner, Kjetil& Johannesen, Tom Børge& Bruland, Øyvind S.. Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009. Complexity. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1076109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1076109