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Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children’s Oncology Group Report
المؤلفون المشاركون
Randall, R. Lor
Marcus, Karen J.
Marina, Neyssa
Granowetter, Linda
Grier, Holcombe E.
Womer, Richard B.
McIlvaine, Elizabeth
Krailo, Mark
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
To associate baseline patient characteristics and relapse across consecutive COG studies.
Methods.
We analyzed risk factors for LESFT patients in three randomized COG trials.
We evaluated age at enrollment, primary site, gender, tumor size, and treatment (as randomized).
We estimated event-free survival (EFS, Kaplan-Meier) and compared risk across groups (log-rank test).
Characteristics were assessed by proportional hazards regression with the characteristic of interest as the only component.
Confidence intervals (CI) for RR were derived.
Factors related to outcome at level 0.05 were included in a multivariate regression model.
Results.
Between 12/1988 and 8/2005, 1444 patients were enrolled and data current to 2001, 2004, or 2008 were used.
Patients were with a median age of 12 years (0–45), 55% male and 88% Caucasian.
The 5-year EFS was 68.3% ± 1.3%.
In univariate analysis age, treatment, and tumor location were identified for inclusion in the multivariate model, and all remained significant (p < 0.01).
Since tumor size was not collected in the last study, the other two were reanalyzed.
This model identified age, treatment, tumor location, and tumor size as significant predictors.
Conclusion.
Age > 18 years, pelvic tumor, size > 8 cms, and chemotherapy without ifosfamide/etoposide significantly predict worse outcome.
AEWS0031 is NCT00006734, INT0091 and INT0054 designed before 1993 (unregistered).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marina, Neyssa& Granowetter, Linda& Grier, Holcombe E.& Womer, Richard B.& Randall, R. Lor& Marcus, Karen J.…[et al.]. 2015. Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children’s Oncology Group Report. Complexity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076111
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marina, Neyssa…[et al.]. Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children’s Oncology Group Report. Complexity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1076111
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marina, Neyssa& Granowetter, Linda& Grier, Holcombe E.& Womer, Richard B.& Randall, R. Lor& Marcus, Karen J.…[et al.]. Age, Tumor Characteristics, and Treatment Regimen as Event Predictors in Ewing: A Children’s Oncology Group Report. Complexity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076111
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076111
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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